Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
C8orf33Chromosome 8 open reading frame 33. (228 aa)    
Predicted Functional Partners:
REXO4
REX4 homolog, 3'-5' exonuclease.
   
   0.787
GRWD1
Glutamate rich WD repeat containing 1.
   
   0.780
H0WU26_OTOGA
Uncharacterized protein.
    
   0.767
RPL18A
60S ribosomal protein L18a; Belongs to the eukaryotic ribosomal protein eL20 family.
    
   0.766
RRP8
Ribosomal RNA-processing protein 8; Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone- modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and pr [...]
   
   0.765
ZC3H8
Zinc finger CCCH-type containing 8.
   
   0.763
H0XS63_OTOGA
Ribosomal_L14e domain-containing protein.
    
   0.734
H0Y158_OTOGA
Ribosomal_L14e domain-containing protein.
    
   0.734
KNOP1
SMAP domain-containing protein.
    
   0.723
H0XYZ3_OTOGA
SMAP domain-containing protein.
    
   0.723
Your Current Organism:
Otolemur garnettii
NCBI taxonomy Id: 30611
Other names: Galago garnetti, Galago garnettii, O. garnettii, small-eared galago
Server load: low (14%) [HD]