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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NCSTNNicastrin. (709 aa)    
Predicted Functional Partners:
APH1A
Aph-1 homolog A, gamma-secretase subunit.
   
 0.999
PSEN2
Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.
   
 0.999
H0XZG3_OTOGA
Uncharacterized protein.
   
 0.999
PSENEN
Presenilin enhancer, gamma-secretase subunit.
    
 0.998
APH1B
Aph-1 homolog B, gamma-secretase subunit.
   
 0.997
H0XAK4_OTOGA
Uncharacterized protein.
    
 0.984
CRB2
Crumbs cell polarity complex component 2.
    
 0.939
APLP2
Amyloid beta precursor like protein 2.
    
 0.935
NOTCH2
Notch receptor 2.
    
 0.886
NOTCH4
Notch receptor 4.
    
 0.884
Your Current Organism:
Otolemur garnettii
NCBI taxonomy Id: 30611
Other names: Galago garnetti, Galago garnettii, O. garnettii, small-eared galago
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.