Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
NCSTNNicastrin. (709 aa)    
Predicted Functional Partners:
PSENEN
Presenilin enhancer, gamma-secretase subunit.
    
 0.999
APH1A
Aph-1 homolog A, gamma-secretase subunit.
   
 0.999
APH1B
Aph-1 homolog B, gamma-secretase subunit.
   
 0.999
H0XZG3_OTOGA
Uncharacterized protein.
   
 0.999
PSEN2
Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.
   
 0.998
H0XAK4_OTOGA
Uncharacterized protein.
    
 0.979
NOTCH4
Notch receptor 4.
    
 0.957
NOTCH2
Notch receptor 2.
    
 0.957
NOTCH3
Notch receptor 3.
    
 0.953
APLP2
Amyloid beta precursor like protein 2.
    
 0.918
Your Current Organism:
Otolemur garnettii
NCBI taxonomy Id: 30611
Other names: Galago garnetti, Galago garnettii, O. garnettii, small-eared galago
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