PIAS4 protein (Otolemur garnettii) - STRING interaction network

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Score

PIAS4

Protein inhibitor of activated STAT 4. (511 aa)

Predicted Functional Partners:

UBE2I

0.997

H0XQT3_OTOGA

0.991

H0Y0J5_OTOGA

0.986

SUMO3

0.983

SUMO1

0.982

RNF168

0.976

TP53

0.976

PIAS1

0.971

IKBKG

0.969

PRKCZ

0.968

Your Current Organism:

Otolemur garnettii

NCBI taxonomy Id: 30611
Other names: Galago garnetti, Galago garnettii, O. garnettii, small-eared galago

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
H0XQT3_OTOGA	H0Y0J5_OTOGA	ENSOGAP00000018475	ENSOGAP00000021888	Small ubiquitin-related modifier.	Small ubiquitin-related modifier.	0.948
H0XQT3_OTOGA	IKBKG	ENSOGAP00000018475	ENSOGAP00000018084	Small ubiquitin-related modifier.	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	0.422
H0XQT3_OTOGA	PIAS1	ENSOGAP00000018475	ENSOGAP00000012663	Small ubiquitin-related modifier.	Protein inhibitor of activated STAT 1.	0.973
H0XQT3_OTOGA	PIAS4	ENSOGAP00000018475	ENSOGAP00000001477	Small ubiquitin-related modifier.	Protein inhibitor of activated STAT 4.	0.991
H0XQT3_OTOGA	PRKCZ	ENSOGAP00000018475	ENSOGAP00000001452	Small ubiquitin-related modifier.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.878
H0XQT3_OTOGA	RNF168	ENSOGAP00000018475	ENSOGAP00000001068	Small ubiquitin-related modifier.	E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...]	0.682
H0XQT3_OTOGA	SUMO1	ENSOGAP00000018475	ENSOGAP00000019503	Small ubiquitin-related modifier.	Ubiquitin-like domain-containing protein.	0.923
H0XQT3_OTOGA	TP53	ENSOGAP00000018475	ENSOGAP00000015106	Small ubiquitin-related modifier.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.955
H0XQT3_OTOGA	UBE2I	ENSOGAP00000018475	ENSOGAP00000001269	Small ubiquitin-related modifier.	Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family.	0.989
H0Y0J5_OTOGA	H0XQT3_OTOGA	ENSOGAP00000021888	ENSOGAP00000018475	Small ubiquitin-related modifier.	Small ubiquitin-related modifier.	0.948
H0Y0J5_OTOGA	IKBKG	ENSOGAP00000021888	ENSOGAP00000018084	Small ubiquitin-related modifier.	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	0.844
H0Y0J5_OTOGA	PIAS1	ENSOGAP00000021888	ENSOGAP00000012663	Small ubiquitin-related modifier.	Protein inhibitor of activated STAT 1.	0.994
H0Y0J5_OTOGA	PIAS4	ENSOGAP00000021888	ENSOGAP00000001477	Small ubiquitin-related modifier.	Protein inhibitor of activated STAT 4.	0.986
H0Y0J5_OTOGA	PRKCZ	ENSOGAP00000021888	ENSOGAP00000001452	Small ubiquitin-related modifier.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.877
H0Y0J5_OTOGA	RNF168	ENSOGAP00000021888	ENSOGAP00000001068	Small ubiquitin-related modifier.	E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...]	0.764
H0Y0J5_OTOGA	SUMO3	ENSOGAP00000021888	ENSOGAP00000004215	Small ubiquitin-related modifier.	Small ubiquitin-related modifier.	0.923
H0Y0J5_OTOGA	TP53	ENSOGAP00000021888	ENSOGAP00000015106	Small ubiquitin-related modifier.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.996
H0Y0J5_OTOGA	UBE2I	ENSOGAP00000021888	ENSOGAP00000001269	Small ubiquitin-related modifier.	Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family.	0.998
IKBKG	H0XQT3_OTOGA	ENSOGAP00000018084	ENSOGAP00000018475	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	Small ubiquitin-related modifier.	0.422
IKBKG	H0Y0J5_OTOGA	ENSOGAP00000018084	ENSOGAP00000021888	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	Small ubiquitin-related modifier.	0.844