Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Score
ACMSD2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; Converts alpha-amino-beta-carboxymuconate-epsilon- semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). Belongs to the metallo-dependent hydrolases superfamily. (336 aa)    
Predicted Functional Partners:
HAAO
3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate; Belongs to the 3-HAO family.
  
 
 0.988
KYNU
Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. Belongs to the kynureninase family.
 
  
 0.931
ALDH8A1
Aldehyde dehydrogenase 8 family member A1; Belongs to the aldehyde dehydrogenase family.
  
 
 0.914
SENP8
SUMO peptidase family member, NEDD8 specific.
    
 0.839
KMO
Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract.
 
  
 0.836
ALDH1A3
Aldehyde dehydrogenase 1 family member A3; Belongs to the aldehyde dehydrogenase family.
  
 
 0.817
ALDH3B2
Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.
    
 0.806
ALDH3B1
Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.
    
 0.806
ALDH3A1
Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.
    
 0.798
ALDH3A2
Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.
    
 0.751
Your Current Organism:
Otolemur garnettii
NCBI taxonomy Id: 30611
Other names: Galago garnetti, Galago garnettii, O. garnettii, small-eared galago
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