Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
F11Coagulation factor XI; Belongs to the peptidase S1 family. (627 aa)    
Predicted Functional Partners:
NME8
NME/NM23 family member 8.
    
 0.622
WDR90
WD repeat domain 90.
    
 0.591
LOC100940384
Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.
  
 
   0.496
MET
Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]
    
  0.495
TNS2
Tensin 2.
    
  0.455
TNS3
Tensin 3.
    
  0.455
TNS1
Tensin 1.
    
  0.455
SPINT2
Serine peptidase inhibitor, Kunitz type 2.
    
  0.454
F12
Coagulation factor XII.
  
 
 
0.440
AASDH
Aminoadipate-semialdehyde dehydrogenase.
     
  0.432
Your Current Organism:
Otolemur garnettii
NCBI taxonomy Id: 30611
Other names: Galago garnetti, Galago garnettii, O. garnettii, small-eared galago
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