Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
TOPBP1DNA topoisomerase II binding protein 1. (1518 aa)    
Predicted Functional Partners:
BRIP1
BRCA1 interacting protein C-terminal helicase 1.
   
 0.997
RHNO1
RAD9-HUS1-RAD1 interacting nuclear orphan 1.
    
 0.997
TICRR
TOPBP1 interacting checkpoint and replication regulator.
    
 
 0.995
BARD1
BRCA1 associated RING domain 1.
   
 0.994
ATR
ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.
    
 0.993
ATRIP
ATR interacting protein.
    
 0.992
RAD9A
Cell cycle checkpoint control protein; Belongs to the rad9 family.
    
 0.992
CHEK1
Checkpoint kinase 1.
   
 0.988
RTEL1
Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...]
   
 0.987
CLSPN
Claspin.
   
 0.985
Your Current Organism:
Otolemur garnettii
NCBI taxonomy Id: 30611
Other names: Galago garnetti, Galago garnettii, O. garnettii, small-eared galago
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