Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
TICAM2TIR domain-containing protein. (235 aa)    
Predicted Functional Partners:
TLR4
Toll like receptor 4; Belongs to the Toll-like receptor family.
    
 0.989
TRAF6
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
    
 0.988
TLR3
Toll like receptor 3; Belongs to the Toll-like receptor family.
    
 0.988
TRAF3
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
    
 0.981
RIPK1
Receptor interacting serine/threonine kinase 1.
    
 0.973
TMED2
Transmembrane p24 trafficking protein 2.
   
 0.939
TBK1
TANK binding kinase 1.
    
 0.937
MAP3K7
Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
    
 0.934
TMED10
Transmembrane p24 trafficking protein 10.
   
 0.931
TRAF5
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
    
 0.922
Your Current Organism:
Otolemur garnettii
NCBI taxonomy Id: 30611
Other names: Galago garnetti, Galago garnettii, O. garnettii, small-eared galago
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