NGLY1 protein (Otolemur garnettii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

NGLY1

N-glycanase 1. (655 aa)

Predicted Functional Partners:

RAD23B

0.998

RAD23A

0.988

AMFR

0.988

VCP

0.983

DERL1

0.977

UBXN1

0.971

UBXN2B

0.950

SPATA5

0.924

SPATA5L1

0.924

TRAFD1

0.907

Your Current Organism:

Otolemur garnettii

NCBI taxonomy Id: 30611
Other names: Galago garnetti, Galago garnettii, O. garnettii, small-eared galago

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMFR	DERL1	ENSOGAP00000013332	ENSOGAP00000006224	Autocrine motility factor receptor.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.998
AMFR	NGLY1	ENSOGAP00000013332	ENSOGAP00000002139	Autocrine motility factor receptor.	N-glycanase 1.	0.988
AMFR	RAD23A	ENSOGAP00000013332	ENSOGAP00000006884	Autocrine motility factor receptor.	RAD23 homolog A, nucleotide excision repair protein.	0.687
AMFR	RAD23B	ENSOGAP00000013332	ENSOGAP00000012736	Autocrine motility factor receptor.	RAD23 homolog B, nucleotide excision repair protein.	0.943
AMFR	SPATA5	ENSOGAP00000013332	ENSOGAP00000005347	Autocrine motility factor receptor.	Spermatogenesis associated 5.	0.901
AMFR	SPATA5L1	ENSOGAP00000013332	ENSOGAP00000008482	Autocrine motility factor receptor.	Spermatogenesis associated 5 like 1.	0.901
AMFR	UBXN1	ENSOGAP00000013332	ENSOGAP00000010221	Autocrine motility factor receptor.	UBX domain protein 1.	0.991
AMFR	UBXN2B	ENSOGAP00000013332	ENSOGAP00000020573	Autocrine motility factor receptor.	UBX domain protein 2B.	0.469
AMFR	VCP	ENSOGAP00000013332	ENSOGAP00000007713	Autocrine motility factor receptor.	Valosin containing protein; Belongs to the AAA ATPase family.	0.994
DERL1	AMFR	ENSOGAP00000006224	ENSOGAP00000013332	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Autocrine motility factor receptor.	0.998
DERL1	NGLY1	ENSOGAP00000006224	ENSOGAP00000002139	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	N-glycanase 1.	0.977
DERL1	RAD23A	ENSOGAP00000006224	ENSOGAP00000006884	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	RAD23 homolog A, nucleotide excision repair protein.	0.730
DERL1	RAD23B	ENSOGAP00000006224	ENSOGAP00000012736	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	RAD23 homolog B, nucleotide excision repair protein.	0.861
DERL1	SPATA5	ENSOGAP00000006224	ENSOGAP00000005347	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Spermatogenesis associated 5.	0.929
DERL1	SPATA5L1	ENSOGAP00000006224	ENSOGAP00000008482	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Spermatogenesis associated 5 like 1.	0.929
DERL1	UBXN1	ENSOGAP00000006224	ENSOGAP00000010221	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	UBX domain protein 1.	0.984
DERL1	UBXN2B	ENSOGAP00000006224	ENSOGAP00000020573	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	UBX domain protein 2B.	0.857
DERL1	VCP	ENSOGAP00000006224	ENSOGAP00000007713	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Valosin containing protein; Belongs to the AAA ATPase family.	0.997
NGLY1	AMFR	ENSOGAP00000002139	ENSOGAP00000013332	N-glycanase 1.	Autocrine motility factor receptor.	0.988
NGLY1	DERL1	ENSOGAP00000002139	ENSOGAP00000006224	N-glycanase 1.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.977