STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
METHepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1382 aa)    
Predicted Functional Partners:
GAB1
GRB2 associated binding protein 1.
    
 0.998
HGF
Hepatocyte growth factor; Belongs to the peptidase S1 family.
    
 0.995
CBL
Cbl proto-oncogene.
    
 0.992
ARL15
ADP ribosylation factor like GTPase 15.
  
  0.990
ARF6
ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family.
  
 0.990
CBLB
Cbl proto-oncogene B.
    
 0.989
CBLC
Cbl proto-oncogene C.
   
 0.988
SH3KBP1
SH3 domain containing kinase binding protein 1.
   
 0.987
LRIG1
Leucine rich repeats and immunoglobulin like domains 1.
    
 0.985
GRB2
Growth factor receptor bound protein 2.
    
 0.985
Your Current Organism:
Otolemur garnettii
NCBI taxonomy Id: 30611
Other names: Galago garnetti, Galago garnettii, O. garnettii, small-eared galago
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