Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
MEGF6Multiple EGF like domains 6. (1544 aa)    
Predicted Functional Partners:
WRAP73
WD repeat containing, antisense to TP73.
    
 
 0.678
MET
Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]
    
 0.607
ZBTB40
Zinc finger and BTB domain containing 40.
    
 0.605
HMGXB4
HMG-box containing 4.
      
 0.602
LTN1
Listerin E3 ubiquitin protein ligase 1.
      
 0.599
RITA1
RBPJ interacting and tubulin associated 1.
      
 0.589
CTNNAL1
Catenin alpha like 1.
    
 0.581
MYSM1
Myb like, SWIRM and MPN domains 1.
    
  0.555
SERINC2
Serine incorporator 2.
      
 0.527
H0Y0F3_OTOGA
DH domain-containing protein.
    
 0.513
Your Current Organism:
Otolemur garnettii
NCBI taxonomy Id: 30611
Other names: Galago garnetti, Galago garnettii, O. garnettii, small-eared galago
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