STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
STK4Serine/threonine-protein kinase 4 18kDa subunit; Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regul [...] (487 aa)    
Predicted Functional Partners:
H0X220_OTOGA
Uncharacterized protein.
    
 0.989
RASSF1
Ras association domain family member 1.
    
 0.989
SAV1
Salvador family WW domain containing protein 1.
    
 0.988
STK3
Serine/threonine kinase 3.
  
 
 
0.970
RASSF2
Ras association domain family member 2.
    
 0.957
H0WMW6_OTOGA
Uncharacterized protein.
   
 0.956
H0XLI4_OTOGA
Uncharacterized protein.
   
 0.956
H0Y264_OTOGA
Uncharacterized protein.
   
 0.956
LATS2
Non-specific serine/threonine protein kinase.
    
0.953
LATS1
Large tumor suppressor kinase 1.
    
0.953
Your Current Organism:
Otolemur garnettii
NCBI taxonomy Id: 30611
Other names: Galago garnetti, Galago garnettii, O. garnettii, small-eared galago
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