Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
DBNLDrebrin like. (437 aa)    
Predicted Functional Partners:
SH2D4A
SH2 domain containing 4A.
    
 
 0.927
CAPZB
F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
   
 0.877
CAP1
Adenylyl cyclase-associated protein; Belongs to the CAP family.
   
 
 0.853
H0XXU4_OTOGA
Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.
   
 
 0.843
HIP1
Huntingtin interacting protein 1.
    
 
 0.830
HIP1R
Huntingtin interacting protein 1 related.
    
 
 0.830
ZMYND8
Zinc finger MYND-type containing 8.
    
   0.829
CAP2
Adenylyl cyclase-associated protein; Belongs to the CAP family.
   
 
 0.828
WAS
WASP actin nucleation promoting factor.
   
 
 0.824
WASL
WASP like actin nucleation promoting factor.
   
 
 0.824
Your Current Organism:
Otolemur garnettii
NCBI taxonomy Id: 30611
Other names: Galago garnetti, Galago garnettii, O. garnettii, small-eared galago
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