Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
BCL2L1BCL2 like 1. (233 aa)    
Predicted Functional Partners:
BCL2
BCL2 apoptosis regulator.
    
0.998
BCL2L11
BCL2 like 11.
    
 0.998
BAD
BCL2 associated agonist of cell death.
   
 0.997
BAK1
BCL2 antagonist/killer 1.
    
0.997
BBC3
Uncharacterized protein.
    
 0.997
H0WLJ8_OTOGA
BH3-interacting domain death agonist; Counters the protective effect of Bcl-2.
    
 0.996
BAX
BCL2 associated X, apoptosis regulator.
    
0.994
BIK
BCL2 interacting killer.
    
 0.992
TP53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 0.990
MAPK8
Mitogen-activated protein kinase.
    
 0.986
Your Current Organism:
Otolemur garnettii
NCBI taxonomy Id: 30611
Other names: Galago garnetti, Galago garnettii, O. garnettii, small-eared galago
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