PDCD4 protein (Otolemur garnettii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Otolemur garnettii

NCBI taxonomy Id: 30611
Other names: Galago garnetti, Galago garnettii, O. garnettii, small-eared galago

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGO2	PDCD4	ENSOGAP00000007102	ENSOGAP00000011272	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Programmed cell death 4.	0.846
BTRC	FBXW11	ENSOGAP00000013103	ENSOGAP00000010724	Beta-transducin repeat containing E3 ubiquitin protein ligase.	F-box and WD repeat domain containing 11.	0.999
BTRC	PDCD4	ENSOGAP00000013103	ENSOGAP00000011272	Beta-transducin repeat containing E3 ubiquitin protein ligase.	Programmed cell death 4.	0.973
EIF3A	EIF4A1	ENSOGAP00000004087	ENSOGAP00000007278	Eukaryotic translation initiation factor 3 subunit A; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre- initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termi [...]	Eukaryotic translation initiation factor 4A1; Belongs to the DEAD box helicase family.	0.958
EIF3A	EIF4A2	ENSOGAP00000004087	ENSOGAP00000009602	Eukaryotic translation initiation factor 3 subunit A; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre- initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termi [...]	Eukaryotic translation initiation factor 4A2; Belongs to the DEAD box helicase family.	0.929
EIF3A	EIF4G1	ENSOGAP00000004087	ENSOGAP00000013701	Eukaryotic translation initiation factor 3 subunit A; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre- initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termi [...]	Eukaryotic translation initiation factor 4 gamma 1.	0.966
EIF3A	H0XTA4_OTOGA	ENSOGAP00000004087	ENSOGAP00000019346	Eukaryotic translation initiation factor 3 subunit A; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre- initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termi [...]	DEAD domain-containing protein.	0.958
EIF3A	PDCD4	ENSOGAP00000004087	ENSOGAP00000011272	Eukaryotic translation initiation factor 3 subunit A; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre- initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termi [...]	Programmed cell death 4.	0.869
EIF4A1	EIF3A	ENSOGAP00000007278	ENSOGAP00000004087	Eukaryotic translation initiation factor 4A1; Belongs to the DEAD box helicase family.	Eukaryotic translation initiation factor 3 subunit A; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre- initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termi [...]	0.958
EIF4A1	EIF4A2	ENSOGAP00000007278	ENSOGAP00000009602	Eukaryotic translation initiation factor 4A1; Belongs to the DEAD box helicase family.	Eukaryotic translation initiation factor 4A2; Belongs to the DEAD box helicase family.	0.998
EIF4A1	EIF4A3	ENSOGAP00000007278	ENSOGAP00000006705	Eukaryotic translation initiation factor 4A1; Belongs to the DEAD box helicase family.	Uncharacterized protein; Belongs to the DEAD box helicase family.	0.981
EIF4A1	EIF4G1	ENSOGAP00000007278	ENSOGAP00000013701	Eukaryotic translation initiation factor 4A1; Belongs to the DEAD box helicase family.	Eukaryotic translation initiation factor 4 gamma 1.	0.991
EIF4A1	H0Y1C6_OTOGA	ENSOGAP00000007278	ENSOGAP00000022169	Eukaryotic translation initiation factor 4A1; Belongs to the DEAD box helicase family.	Uncharacterized protein; Belongs to the DEAD box helicase family.	0.981
EIF4A1	PDCD4	ENSOGAP00000007278	ENSOGAP00000011272	Eukaryotic translation initiation factor 4A1; Belongs to the DEAD box helicase family.	Programmed cell death 4.	0.964
EIF4A2	EIF3A	ENSOGAP00000009602	ENSOGAP00000004087	Eukaryotic translation initiation factor 4A2; Belongs to the DEAD box helicase family.	Eukaryotic translation initiation factor 3 subunit A; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre- initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termi [...]	0.929
EIF4A2	EIF4A1	ENSOGAP00000009602	ENSOGAP00000007278	Eukaryotic translation initiation factor 4A2; Belongs to the DEAD box helicase family.	Eukaryotic translation initiation factor 4A1; Belongs to the DEAD box helicase family.	0.998
EIF4A2	EIF4A3	ENSOGAP00000009602	ENSOGAP00000006705	Eukaryotic translation initiation factor 4A2; Belongs to the DEAD box helicase family.	Uncharacterized protein; Belongs to the DEAD box helicase family.	0.992
EIF4A2	EIF4G1	ENSOGAP00000009602	ENSOGAP00000013701	Eukaryotic translation initiation factor 4A2; Belongs to the DEAD box helicase family.	Eukaryotic translation initiation factor 4 gamma 1.	0.998
EIF4A2	H0XTA4_OTOGA	ENSOGAP00000009602	ENSOGAP00000019346	Eukaryotic translation initiation factor 4A2; Belongs to the DEAD box helicase family.	DEAD domain-containing protein.	0.997
EIF4A2	H0Y1C6_OTOGA	ENSOGAP00000009602	ENSOGAP00000022169	Eukaryotic translation initiation factor 4A2; Belongs to the DEAD box helicase family.	Uncharacterized protein; Belongs to the DEAD box helicase family.	0.992