KAT5 protein (Otolemur garnettii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Otolemur garnettii

NCBI taxonomy Id: 30611
Other names: Galago garnetti, Galago garnettii, O. garnettii, small-eared galago

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATM	EP400	ENSOGAP00000015450	ENSOGAP00000002431	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	E1A binding protein p400.	0.441
ATM	KAT5	ENSOGAP00000015450	ENSOGAP00000012652	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	0.997
ATM	TRRAP	ENSOGAP00000015450	ENSOGAP00000000581	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Transformation/transcription domain associated protein; Belongs to the PI3/PI4-kinase family.	0.535
DMAP1	EP400	ENSOGAP00000009683	ENSOGAP00000002431	DNA methyltransferase 1 associated protein 1.	E1A binding protein p400.	0.992
DMAP1	H0WMP6_OTOGA	ENSOGAP00000009683	ENSOGAP00000003028	DNA methyltransferase 1 associated protein 1.	Bromo domain-containing protein.	0.996
DMAP1	ING3	ENSOGAP00000009683	ENSOGAP00000003761	DNA methyltransferase 1 associated protein 1.	Inhibitor of growth protein.	0.996
DMAP1	KAT5	ENSOGAP00000009683	ENSOGAP00000012652	DNA methyltransferase 1 associated protein 1.	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	0.996
DMAP1	MEAF6	ENSOGAP00000009683	ENSOGAP00000006060	DNA methyltransferase 1 associated protein 1.	MYST/Esa1 associated factor 6.	0.989
DMAP1	MRGBP	ENSOGAP00000009683	ENSOGAP00000020519	DNA methyltransferase 1 associated protein 1.	MRG domain binding protein.	0.996
DMAP1	RUVBL1	ENSOGAP00000009683	ENSOGAP00000012611	DNA methyltransferase 1 associated protein 1.	RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding.	0.994
DMAP1	RUVBL2	ENSOGAP00000009683	ENSOGAP00000006725	DNA methyltransferase 1 associated protein 1.	RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding.	0.994
DMAP1	TRRAP	ENSOGAP00000009683	ENSOGAP00000000581	DNA methyltransferase 1 associated protein 1.	Transformation/transcription domain associated protein; Belongs to the PI3/PI4-kinase family.	0.992
EP400	ATM	ENSOGAP00000002431	ENSOGAP00000015450	E1A binding protein p400.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.441
EP400	DMAP1	ENSOGAP00000002431	ENSOGAP00000009683	E1A binding protein p400.	DNA methyltransferase 1 associated protein 1.	0.992
EP400	H0WMP6_OTOGA	ENSOGAP00000002431	ENSOGAP00000003028	E1A binding protein p400.	Bromo domain-containing protein.	0.995
EP400	ING3	ENSOGAP00000002431	ENSOGAP00000003761	E1A binding protein p400.	Inhibitor of growth protein.	0.985
EP400	KAT5	ENSOGAP00000002431	ENSOGAP00000012652	E1A binding protein p400.	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	0.996
EP400	MEAF6	ENSOGAP00000002431	ENSOGAP00000006060	E1A binding protein p400.	MYST/Esa1 associated factor 6.	0.994
EP400	MRGBP	ENSOGAP00000002431	ENSOGAP00000020519	E1A binding protein p400.	MRG domain binding protein.	0.998
EP400	RUVBL1	ENSOGAP00000002431	ENSOGAP00000012611	E1A binding protein p400.	RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding.	0.994