EHMT2 protein (Otolemur garnettii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

EHMT2

Uncharacterized protein. (1270 aa)

Predicted Functional Partners:

EHMT1

0.993

HDAC1

0.972

CBX5

0.960

CBX1

0.957

H0X3T0_OTOGA

0.951

HDAC2

0.940

PLOD2

0.936

DNMT1

0.920

SETDB1

0.919

KDM1A

0.918

Your Current Organism:

Otolemur garnettii

NCBI taxonomy Id: 30611
Other names: Galago garnetti, Galago garnettii, O. garnettii, small-eared galago

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CBX1	CBX5	ENSOGAP00000005054	ENSOGAP00000012061	Chromobox 1.	Chromobox 5.	0.969
CBX1	DNMT1	ENSOGAP00000005054	ENSOGAP00000001132	Chromobox 1.	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.801
CBX1	EHMT1	ENSOGAP00000005054	ENSOGAP00000000118	Chromobox 1.	Euchromatic histone lysine methyltransferase 1.	0.830
CBX1	EHMT2	ENSOGAP00000005054	ENSOGAP00000012706	Chromobox 1.	Uncharacterized protein.	0.957
CBX1	H0X3T0_OTOGA	ENSOGAP00000005054	ENSOGAP00000009805	Chromobox 1.	Uncharacterized protein.	0.763
CBX1	HDAC1	ENSOGAP00000005054	ENSOGAP00000005101	Chromobox 1.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.461
CBX1	KDM1A	ENSOGAP00000005054	ENSOGAP00000001931	Chromobox 1.	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	0.614
CBX1	SETDB1	ENSOGAP00000005054	ENSOGAP00000009233	Chromobox 1.	SET domain bifurcated histone lysine methyltransferase 1.	0.762
CBX5	CBX1	ENSOGAP00000012061	ENSOGAP00000005054	Chromobox 5.	Chromobox 1.	0.969
CBX5	DNMT1	ENSOGAP00000012061	ENSOGAP00000001132	Chromobox 5.	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.876
CBX5	EHMT1	ENSOGAP00000012061	ENSOGAP00000000118	Chromobox 5.	Euchromatic histone lysine methyltransferase 1.	0.923
CBX5	EHMT2	ENSOGAP00000012061	ENSOGAP00000012706	Chromobox 5.	Uncharacterized protein.	0.960
CBX5	H0X3T0_OTOGA	ENSOGAP00000012061	ENSOGAP00000009805	Chromobox 5.	Uncharacterized protein.	0.880
CBX5	HDAC1	ENSOGAP00000012061	ENSOGAP00000005101	Chromobox 5.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.458
CBX5	KDM1A	ENSOGAP00000012061	ENSOGAP00000001931	Chromobox 5.	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	0.614
CBX5	SETDB1	ENSOGAP00000012061	ENSOGAP00000009233	Chromobox 5.	SET domain bifurcated histone lysine methyltransferase 1.	0.754
DNMT1	CBX1	ENSOGAP00000001132	ENSOGAP00000005054	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Chromobox 1.	0.801
DNMT1	CBX5	ENSOGAP00000001132	ENSOGAP00000012061	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Chromobox 5.	0.876
DNMT1	EHMT1	ENSOGAP00000001132	ENSOGAP00000000118	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Euchromatic histone lysine methyltransferase 1.	0.843
DNMT1	EHMT2	ENSOGAP00000001132	ENSOGAP00000012706	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Uncharacterized protein.	0.920