RPA2 protein (Otolemur garnettii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Otolemur garnettii

NCBI taxonomy Id: 30611
Other names: Galago garnetti, Galago garnettii, O. garnettii, small-eared galago

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structured XML interaction data, according to the 'PSI-MI' data standard

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... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BLM	H0WHP7_OTOGA	ENSOGAP00000005104	ENSOGAP00000000910	BLM RecQ like helicase.	Uncharacterized protein.	0.989
BLM	H0XNJ8_OTOGA	ENSOGAP00000005104	ENSOGAP00000017689	BLM RecQ like helicase.	Uncharacterized protein.	0.992
BLM	POLA1	ENSOGAP00000005104	ENSOGAP00000012725	BLM RecQ like helicase.	DNA polymerase.	0.812
BLM	POLD1	ENSOGAP00000005104	ENSOGAP00000004850	BLM RecQ like helicase.	DNA polymerase.	0.811
BLM	RMI1	ENSOGAP00000005104	ENSOGAP00000018015	BLM RecQ like helicase.	RecQ mediated genome instability 1.	0.999
BLM	RPA1	ENSOGAP00000005104	ENSOGAP00000017150	BLM RecQ like helicase.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.992
BLM	RPA2	ENSOGAP00000005104	ENSOGAP00000013958	BLM RecQ like helicase.	Replication protein A2.	0.960
BLM	RPA3	ENSOGAP00000005104	ENSOGAP00000016085	BLM RecQ like helicase.	Uncharacterized protein.	0.989
BLM	TOP3A	ENSOGAP00000005104	ENSOGAP00000011540	BLM RecQ like helicase.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.999
H0WHP7_OTOGA	BLM	ENSOGAP00000000910	ENSOGAP00000005104	Uncharacterized protein.	BLM RecQ like helicase.	0.989
H0WHP7_OTOGA	H0XNJ8_OTOGA	ENSOGAP00000000910	ENSOGAP00000017689	Uncharacterized protein.	Uncharacterized protein.	0.986
H0WHP7_OTOGA	POLA1	ENSOGAP00000000910	ENSOGAP00000012725	Uncharacterized protein.	DNA polymerase.	0.944
H0WHP7_OTOGA	POLA2	ENSOGAP00000000910	ENSOGAP00000013164	Uncharacterized protein.	DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.	0.810
H0WHP7_OTOGA	POLD1	ENSOGAP00000000910	ENSOGAP00000004850	Uncharacterized protein.	DNA polymerase.	0.982
H0WHP7_OTOGA	RMI1	ENSOGAP00000000910	ENSOGAP00000018015	Uncharacterized protein.	RecQ mediated genome instability 1.	0.989
H0WHP7_OTOGA	RPA1	ENSOGAP00000000910	ENSOGAP00000017150	Uncharacterized protein.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.986
H0WHP7_OTOGA	RPA2	ENSOGAP00000000910	ENSOGAP00000013958	Uncharacterized protein.	Replication protein A2.	0.984
H0WHP7_OTOGA	RPA3	ENSOGAP00000000910	ENSOGAP00000016085	Uncharacterized protein.	Uncharacterized protein.	0.543
H0WHP7_OTOGA	TOP3A	ENSOGAP00000000910	ENSOGAP00000011540	Uncharacterized protein.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.989
H0XNJ8_OTOGA	BLM	ENSOGAP00000017689	ENSOGAP00000005104	Uncharacterized protein.	BLM RecQ like helicase.	0.992