STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
IRS1Insulin receptor substrate 1. (1233 aa)    
Predicted Functional Partners:
PIK3R1
Phosphoinositide-3-kinase regulatory subunit 1.
    
 0.946
PTPN11
Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.
    
 0.945
GRB2
Growth factor receptor bound protein 2.
    
 0.944
INSR
Tyrosine-protein kinase receptor.
    
 0.930
IGF1R
Tyrosine-protein kinase receptor.
    
 0.928
H0WHZ3_OTOGA
Uncharacterized protein.
    
 0.916
H0WU85_OTOGA
Uncharacterized protein.
    
 0.916
PIK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.
   
 0.912
PIK3CB
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.
   
 0.903
PIK3CD
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.
   
 0.901
Your Current Organism:
Otolemur garnettii
NCBI taxonomy Id: 30611
Other names: Galago garnetti, Galago garnettii, O. garnettii, small-eared galago
Server load: medium (50%) [HD]