| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CCND1 | CDK2 | ENSOGAP00000010293 | ENSOGAP00000006310 | Cyclin D1; Belongs to the cyclin family. | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. | 0.998 |
| CCND1 | CDK4 | ENSOGAP00000010293 | ENSOGAP00000012878 | Cyclin D1; Belongs to the cyclin family. | Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. | 0.999 |
| CCND1 | MCM7 | ENSOGAP00000010293 | ENSOGAP00000015080 | Cyclin D1; Belongs to the cyclin family. | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | 0.412 |
| CCND1 | PCNA | ENSOGAP00000010293 | ENSOGAP00000017004 | Cyclin D1; Belongs to the cyclin family. | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | 0.998 |
| CDK2 | CCND1 | ENSOGAP00000006310 | ENSOGAP00000010293 | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. | Cyclin D1; Belongs to the cyclin family. | 0.998 |
| CDK2 | CDK4 | ENSOGAP00000006310 | ENSOGAP00000012878 | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. | Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. | 0.994 |
| CDK2 | FEN1 | ENSOGAP00000006310 | ENSOGAP00000018862 | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.445 |
| CDK2 | LIG1 | ENSOGAP00000006310 | ENSOGAP00000000644 | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. | DNA ligase. | 0.807 |
| CDK2 | MCM7 | ENSOGAP00000006310 | ENSOGAP00000015080 | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | 0.757 |
| CDK2 | PCNA | ENSOGAP00000006310 | ENSOGAP00000017004 | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | 0.997 |
| CDK2 | RFC4 | ENSOGAP00000006310 | ENSOGAP00000009604 | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. | Replication factor C subunit 4. | 0.506 |
| CDK4 | CCND1 | ENSOGAP00000012878 | ENSOGAP00000010293 | Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. | Cyclin D1; Belongs to the cyclin family. | 0.999 |
| CDK4 | CDK2 | ENSOGAP00000012878 | ENSOGAP00000006310 | Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. | 0.994 |
| CDK4 | FEN1 | ENSOGAP00000012878 | ENSOGAP00000018862 | Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.445 |
| CDK4 | LIG1 | ENSOGAP00000012878 | ENSOGAP00000000644 | Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. | DNA ligase. | 0.427 |
| CDK4 | MCM7 | ENSOGAP00000012878 | ENSOGAP00000015080 | Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | 0.838 |
| CDK4 | PCNA | ENSOGAP00000012878 | ENSOGAP00000017004 | Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | 0.998 |
| CDK4 | RFC4 | ENSOGAP00000012878 | ENSOGAP00000009604 | Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. | Replication factor C subunit 4. | 0.572 |
| FEN1 | CDK2 | ENSOGAP00000018862 | ENSOGAP00000006310 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. | 0.445 |
| FEN1 | CDK4 | ENSOGAP00000018862 | ENSOGAP00000012878 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. | 0.445 |
