NKX2-2 protein (Otolemur garnettii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Otolemur garnettii

NCBI taxonomy Id: 30611
Other names: Galago garnetti, Galago garnettii, O. garnettii, small-eared galago

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

... network coordinates:

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
H0XHA0_OTOGA	NKX2-2	ENSOGAP00000015490	ENSOGAP00000017651	TLE_N domain-containing protein.	NK2 homeobox 2.	0.699
H0XHA0_OTOGA	TLE1	ENSOGAP00000015490	ENSOGAP00000011577	TLE_N domain-containing protein.	TLE family member 1, transcriptional corepressor.	0.985
H0XHA0_OTOGA	TLE2	ENSOGAP00000015490	ENSOGAP00000014456	TLE_N domain-containing protein.	TLE family member 2, transcriptional corepressor.	0.944
H0XHA0_OTOGA	TLE3	ENSOGAP00000015490	ENSOGAP00000004285	TLE_N domain-containing protein.	TLE family member 3, transcriptional corepressor.	0.937
H0XHA0_OTOGA	TLE4	ENSOGAP00000015490	ENSOGAP00000008669	TLE_N domain-containing protein.	TLE family member 4, transcriptional corepressor.	0.944
INS	NEUROG1	ENSOGAP00000019490	ENSOGAP00000020217	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Neurogenin 1.	0.548
INS	NEUROG3	ENSOGAP00000019490	ENSOGAP00000005300	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Neurogenin 3.	0.548
INS	NKX2-2	ENSOGAP00000019490	ENSOGAP00000017651	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	NK2 homeobox 2.	0.733
NEUROG1	INS	ENSOGAP00000020217	ENSOGAP00000019490	Neurogenin 1.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.548
NEUROG1	NKX2-2	ENSOGAP00000020217	ENSOGAP00000017651	Neurogenin 1.	NK2 homeobox 2.	0.718
NEUROG3	INS	ENSOGAP00000005300	ENSOGAP00000019490	Neurogenin 3.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.548
NEUROG3	NKX2-2	ENSOGAP00000005300	ENSOGAP00000017651	Neurogenin 3.	NK2 homeobox 2.	0.718
NKX2-2	H0XHA0_OTOGA	ENSOGAP00000017651	ENSOGAP00000015490	NK2 homeobox 2.	TLE_N domain-containing protein.	0.699
NKX2-2	INS	ENSOGAP00000017651	ENSOGAP00000019490	NK2 homeobox 2.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.733
NKX2-2	NEUROG1	ENSOGAP00000017651	ENSOGAP00000020217	NK2 homeobox 2.	Neurogenin 1.	0.718
NKX2-2	NEUROG3	ENSOGAP00000017651	ENSOGAP00000005300	NK2 homeobox 2.	Neurogenin 3.	0.718
NKX2-2	NKX2-8	ENSOGAP00000017651	ENSOGAP00000017086	NK2 homeobox 2.	NK2 homeobox 8.	0.727
NKX2-2	TLE1	ENSOGAP00000017651	ENSOGAP00000011577	NK2 homeobox 2.	TLE family member 1, transcriptional corepressor.	0.699
NKX2-2	TLE2	ENSOGAP00000017651	ENSOGAP00000014456	NK2 homeobox 2.	TLE family member 2, transcriptional corepressor.	0.699
NKX2-2	TLE3	ENSOGAP00000017651	ENSOGAP00000004285	NK2 homeobox 2.	TLE family member 3, transcriptional corepressor.	0.798