STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MNX1Motor neuron and pancreas homeobox 1. (289 aa)    
Predicted Functional Partners:
VIPR1
Vasoactive intestinal peptide receptor 1; Belongs to the G-protein coupled receptor 2 family.
      
 0.706
TSPAN2
Tetraspanin.
      
 0.658
EGFR
Receptor protein-tyrosine kinase.
    
 
 0.640
BDNF
Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.
      
 0.637
PTGS1
Prostaglandin-endoperoxide synthase 1.
      
 0.633
CX3CL1
C-X3-C motif chemokine ligand 1.
      
 0.633
GDF15
Growth differentiation factor 15.
      
 0.632
GET3
ATPase ASNA1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...]
   
  
 0.626
ADAMTS3
ADAM metallopeptidase with thrombospondin type 1 motif 3.
   
  
 0.614
TMEM86A
Transmembrane protein 86A.
      
 0.613
Your Current Organism:
Otolemur garnettii
NCBI taxonomy Id: 30611
Other names: Galago garnetti, Galago garnettii, O. garnettii, small-eared galago
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.