| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ATAD5 | DNA2 | ENSOGAP00000001062 | ENSOGAP00000010016 | ATPase family AAA domain containing 5. | DNA replication helicase/nuclease 2. | 0.971 |
| ATAD5 | FEN1 | ENSOGAP00000001062 | ENSOGAP00000018862 | ATPase family AAA domain containing 5. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.977 |
| ATAD5 | LIG1 | ENSOGAP00000001062 | ENSOGAP00000000644 | ATPase family AAA domain containing 5. | DNA ligase. | 0.847 |
| ATAD5 | MRE11 | ENSOGAP00000001062 | ENSOGAP00000010874 | ATPase family AAA domain containing 5. | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. | 0.964 |
| ATAD5 | PCNA | ENSOGAP00000001062 | ENSOGAP00000017004 | ATPase family AAA domain containing 5. | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | 0.985 |
| ATAD5 | POLB | ENSOGAP00000001062 | ENSOGAP00000014463 | ATPase family AAA domain containing 5. | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. | 0.400 |
| ATAD5 | POLD1 | ENSOGAP00000001062 | ENSOGAP00000004850 | ATPase family AAA domain containing 5. | DNA polymerase. | 0.939 |
| ATAD5 | RAD50 | ENSOGAP00000001062 | ENSOGAP00000013879 | ATPase family AAA domain containing 5. | RAD50 homolog isoform 1 (Predicted). | 0.955 |
| ATAD5 | RFC3 | ENSOGAP00000001062 | ENSOGAP00000014989 | ATPase family AAA domain containing 5. | Replication factor C subunit 3. | 0.990 |
| ATAD5 | WRN | ENSOGAP00000001062 | ENSOGAP00000008598 | ATPase family AAA domain containing 5. | WRN RecQ like helicase. | 0.936 |
| DNA2 | ATAD5 | ENSOGAP00000010016 | ENSOGAP00000001062 | DNA replication helicase/nuclease 2. | ATPase family AAA domain containing 5. | 0.971 |
| DNA2 | FEN1 | ENSOGAP00000010016 | ENSOGAP00000018862 | DNA replication helicase/nuclease 2. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.978 |
| DNA2 | LIG1 | ENSOGAP00000010016 | ENSOGAP00000000644 | DNA replication helicase/nuclease 2. | DNA ligase. | 0.733 |
| DNA2 | MRE11 | ENSOGAP00000010016 | ENSOGAP00000010874 | DNA replication helicase/nuclease 2. | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. | 0.976 |
| DNA2 | PCNA | ENSOGAP00000010016 | ENSOGAP00000017004 | DNA replication helicase/nuclease 2. | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | 0.888 |
| DNA2 | POLD1 | ENSOGAP00000010016 | ENSOGAP00000004850 | DNA replication helicase/nuclease 2. | DNA polymerase. | 0.952 |
| DNA2 | RAD50 | ENSOGAP00000010016 | ENSOGAP00000013879 | DNA replication helicase/nuclease 2. | RAD50 homolog isoform 1 (Predicted). | 0.912 |
| DNA2 | RFC3 | ENSOGAP00000010016 | ENSOGAP00000014989 | DNA replication helicase/nuclease 2. | Replication factor C subunit 3. | 0.855 |
| DNA2 | WRN | ENSOGAP00000010016 | ENSOGAP00000008598 | DNA replication helicase/nuclease 2. | WRN RecQ like helicase. | 0.997 |
| FEN1 | ATAD5 | ENSOGAP00000018862 | ENSOGAP00000001062 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | ATPase family AAA domain containing 5. | 0.977 |
