| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| adk | apt | Cla_0648 | Cla_0680 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.934 |
| adk | purB1 | Cla_0648 | Cla_0024 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | Pfam match to PF00206.11 Lyase_1; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.933 |
| adk | surE | Cla_0648 | Cla_1381 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | Stationary-phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.922 |
| apt | adk | Cla_0680 | Cla_0648 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | 0.934 |
| apt | purA | Cla_0680 | Cla_0368 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.519 |
| apt | purB1 | Cla_0680 | Cla_0024 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Pfam match to PF00206.11 Lyase_1; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.941 |
| apt | purC | Cla_0680 | Cla_0709 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Pfam match to PF01259.9 SAICAR_synt; Belongs to the SAICAR synthetase family. | 0.443 |
| apt | purF | Cla_0680 | Cla_1408 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.440 |
| apt | purH | Cla_0680 | Cla_0545 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Pfam matches to PF02142.13 MGS, and to PF01808.9 AICARFT_IMPCHas. | 0.957 |
| apt | surE | Cla_0680 | Cla_1381 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Stationary-phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.918 |
| argH | aspA | Cla_0275 | Cla_0140 | Pfam match to PF00206.11 Lyase_1. | Aspartate ammonia-lyase; Pfam match to PF00206.11 Lyase_1. | 0.908 |
| argH | purB1 | Cla_0275 | Cla_0024 | Pfam match to PF00206.11 Lyase_1. | Pfam match to PF00206.11 Lyase_1; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.909 |
| aspA | argH | Cla_0140 | Cla_0275 | Aspartate ammonia-lyase; Pfam match to PF00206.11 Lyase_1. | Pfam match to PF00206.11 Lyase_1. | 0.908 |
| aspA | purA | Cla_0140 | Cla_0368 | Aspartate ammonia-lyase; Pfam match to PF00206.11 Lyase_1. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.901 |
| aspA | purB1 | Cla_0140 | Cla_0024 | Aspartate ammonia-lyase; Pfam match to PF00206.11 Lyase_1. | Pfam match to PF00206.11 Lyase_1; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.901 |
| purA | apt | Cla_0368 | Cla_0680 | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.519 |
| purA | aspA | Cla_0368 | Cla_0140 | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | Aspartate ammonia-lyase; Pfam match to PF00206.11 Lyase_1. | 0.901 |
| purA | purB1 | Cla_0368 | Cla_0024 | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | Pfam match to PF00206.11 Lyase_1; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.991 |
| purA | purC | Cla_0368 | Cla_0709 | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Pfam match to PF01259.9 SAICAR_synt; Belongs to the SAICAR synthetase family. | 0.749 |
| purA | purD | Cla_0368 | Cla_0504 | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | Phosphoribosylamine--glycine ligase; Pfam matches to PF02844.6 GARS_N, and to PF01071.10 GARS_A; Belongs to the GARS family. | 0.772 |