Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
cosRTwo-component response regulator; Pfam matches to PF00072.15 Response_reg, and to PF00486.19 Trans_reg_C. (224 aa)    
Predicted Functional Partners:
folB
Dihydroneopterin aldolase.
  
  
 0.921
fdxB
Ferredoxin; Pfam match to PF00037.18 Fer4.
   
 
 0.889
rpoB
DNA-directed RNA polymerase, beta chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
 
 0.883
rpoC
DNA-directed RNA polymerase, beta' chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
 
 0.883
cprS
Two-component sensor histidine kinase; Pfam matches to PF00672.16 HAMP, and to PF00512.16 HisKA.
  
 
 0.841
Cla_0127
Two-component sensor histidine kinase; Pfam match to PF02518.17 HATPase_c.
 
   0.834
dccS
Two-component sensor histidine kinase; Pfam matches to PF00512.16 HisKA, and to PF02518.17 HATPase_c.
 
   0.831
nuoK
NADH-quinone oxidoreductase, K subunit; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I subunit 4L family.
    
 
 0.813
csrA
Carbon storage regulator; A translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Usually binds in the 5'- UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding, thus repressing translation. Its main target seems to be the major flagellin gene, while its function is anatagonized by FliW.
      
 0.811
phosS
Two-component sensor histidine kinase; Pfam matches to PF00512.16 HisKA, and to PF02518.17 HATPase_c.
  
 
 0.737
Your Current Organism:
Campylobacter lari
NCBI taxonomy Id: 306263
Other names: C. lari RM2100, Campylobacter lari RM2100, Campylobacter lari str. RM2100, Campylobacter lari strain RM2100
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