STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
purB2Pfam match to PF00206.11 Lyase_1; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (454 aa)    
Predicted Functional Partners:
metC
Cystathionase beta-lyase; Pfam match to PF01053.11 Cys_Met_Meta_PP.
   
 
 0.964
purA
Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
 
 0.949
purC
Phosphoribosylaminoimidazole-succinocarboxamide synthase; Pfam match to PF01259.9 SAICAR_synt; Belongs to the SAICAR synthetase family.
 
 0.921
purH
Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Pfam matches to PF02142.13 MGS, and to PF01808.9 AICARFT_IMPCHas.
  
 0.907
Cla_0281
MmgE/PrpD family protein; Pfam match to PF03972.5 MmgE_PrpD.
 
     0.858
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
  
  
 0.845
purF
Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
  
 
 0.831
purD
Phosphoribosylamine--glycine ligase; Pfam matches to PF02844.6 GARS_N, and to PF01071.10 GARS_A; Belongs to the GARS family.
  
 
 0.825
peb3
Major antigenic peptide PEB3.
      
 0.810
purM
Phosphoribosylaminoimidazole synthetase; Pfam matches to PF00586.15 AIRS, and to PF02769.13 AIRS_C.
  
 
 0.809
Your Current Organism:
Campylobacter lari
NCBI taxonomy Id: 306263
Other names: C. lari RM2100, Campylobacter lari RM2100, Campylobacter lari str. RM2100, Campylobacter lari strain RM2100
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.