| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Cla_0486 | Cla_0490 | Cla_0486 | Cla_0490 | Conserved hypothetical integral membrane protein, CvpA family; Pfam match to PF02674.7 Colicin_V. | Conserved hypothetical protein (DUF1882 domain protein); Pfam match to PF08966.2 DUF1882. | 0.813 |
| Cla_0486 | Cla_0491 | Cla_0486 | Cla_0491 | Conserved hypothetical integral membrane protein, CvpA family; Pfam match to PF02674.7 Colicin_V. | Conserved hypothetical protein; Pfam match to PF05036.4 SPOR. | 0.774 |
| Cla_0486 | aroE | Cla_0486 | Cla_0492 | Conserved hypothetical integral membrane protein, CvpA family; Pfam match to PF02674.7 Colicin_V. | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | 0.774 |
| Cla_0486 | fur | Cla_0486 | Cla_0487 | Conserved hypothetical integral membrane protein, CvpA family; Pfam match to PF02674.7 Colicin_V. | Ferric uptake regulation protein; Pfam match to PF01475.10 FUR; Belongs to the Fur family. | 0.825 |
| Cla_0486 | glyA | Cla_0486 | Cla_0489 | Conserved hypothetical integral membrane protein, CvpA family; Pfam match to PF02674.7 Colicin_V. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.826 |
| Cla_0486 | lysS | Cla_0486 | Cla_0488 | Conserved hypothetical integral membrane protein, CvpA family; Pfam match to PF02674.7 Colicin_V. | lysyl-tRNA synthetase; Pfam matches to PF01336.16 tRNA_anti, and to PF00152.11 tRNA-synt_2; Belongs to the class-II aminoacyl-tRNA synthetase family. | 0.812 |
| Cla_0486 | purC | Cla_0486 | Cla_0709 | Conserved hypothetical integral membrane protein, CvpA family; Pfam match to PF02674.7 Colicin_V. | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Pfam match to PF01259.9 SAICAR_synt; Belongs to the SAICAR synthetase family. | 0.866 |
| Cla_0486 | purE | Cla_0486 | Cla_1004 | Conserved hypothetical integral membrane protein, CvpA family; Pfam match to PF02674.7 Colicin_V. | Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). | 0.845 |
| Cla_0486 | purF | Cla_0486 | Cla_1408 | Conserved hypothetical integral membrane protein, CvpA family; Pfam match to PF02674.7 Colicin_V. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.898 |
| Cla_0486 | purM | Cla_0486 | Cla_0052 | Conserved hypothetical integral membrane protein, CvpA family; Pfam match to PF02674.7 Colicin_V. | Phosphoribosylaminoimidazole synthetase; Pfam matches to PF00586.15 AIRS, and to PF02769.13 AIRS_C. | 0.860 |
| Cla_0490 | Cla_0486 | Cla_0490 | Cla_0486 | Conserved hypothetical protein (DUF1882 domain protein); Pfam match to PF08966.2 DUF1882. | Conserved hypothetical integral membrane protein, CvpA family; Pfam match to PF02674.7 Colicin_V. | 0.813 |
| Cla_0490 | Cla_0491 | Cla_0490 | Cla_0491 | Conserved hypothetical protein (DUF1882 domain protein); Pfam match to PF08966.2 DUF1882. | Conserved hypothetical protein; Pfam match to PF05036.4 SPOR. | 0.787 |
| Cla_0490 | aroE | Cla_0490 | Cla_0492 | Conserved hypothetical protein (DUF1882 domain protein); Pfam match to PF08966.2 DUF1882. | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | 0.787 |
| Cla_0490 | fur | Cla_0490 | Cla_0487 | Conserved hypothetical protein (DUF1882 domain protein); Pfam match to PF08966.2 DUF1882. | Ferric uptake regulation protein; Pfam match to PF01475.10 FUR; Belongs to the Fur family. | 0.812 |
| Cla_0490 | glyA | Cla_0490 | Cla_0489 | Conserved hypothetical protein (DUF1882 domain protein); Pfam match to PF08966.2 DUF1882. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.825 |
| Cla_0490 | lysS | Cla_0490 | Cla_0488 | Conserved hypothetical protein (DUF1882 domain protein); Pfam match to PF08966.2 DUF1882. | lysyl-tRNA synthetase; Pfam matches to PF01336.16 tRNA_anti, and to PF00152.11 tRNA-synt_2; Belongs to the class-II aminoacyl-tRNA synthetase family. | 0.825 |
| Cla_0491 | Cla_0486 | Cla_0491 | Cla_0486 | Conserved hypothetical protein; Pfam match to PF05036.4 SPOR. | Conserved hypothetical integral membrane protein, CvpA family; Pfam match to PF02674.7 Colicin_V. | 0.774 |
| Cla_0491 | Cla_0490 | Cla_0491 | Cla_0490 | Conserved hypothetical protein; Pfam match to PF05036.4 SPOR. | Conserved hypothetical protein (DUF1882 domain protein); Pfam match to PF08966.2 DUF1882. | 0.787 |
| Cla_0491 | aroE | Cla_0491 | Cla_0492 | Conserved hypothetical protein; Pfam match to PF05036.4 SPOR. | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | 0.825 |
| Cla_0491 | fur | Cla_0491 | Cla_0487 | Conserved hypothetical protein; Pfam match to PF05036.4 SPOR. | Ferric uptake regulation protein; Pfam match to PF01475.10 FUR; Belongs to the Fur family. | 0.774 |