node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cla_1278 | guaA | Cla_1278 | Cla_0501 | Putative purine NTP pyrophosphatase - RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.953 |
Cla_1278 | guaB | Cla_1278 | Cla_1159 | Putative purine NTP pyrophosphatase - RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.942 |
Cla_1278 | surE | Cla_1278 | Cla_1381 | Putative purine NTP pyrophosphatase - RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Stationary-phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.900 |
apt | gmk | Cla_0680 | Cla_1089 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.964 |
apt | guaA | Cla_0680 | Cla_0501 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.994 |
apt | guaB | Cla_0680 | Cla_1159 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.562 |
apt | pyrG | Cla_0680 | Cla_0012 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | CTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.476 |
apt | surE | Cla_0680 | Cla_1381 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Stationary-phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.918 |
argS | gmk | Cla_1087 | Cla_1089 | arginyl-tRNA synthetase; Pfam matches to PF03485.7 Arg_tRNA_synt_N, and to PF00750.10 tRNA-synt_1d. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.976 |
argS | guaA | Cla_1087 | Cla_0501 | arginyl-tRNA synthetase; Pfam matches to PF03485.7 Arg_tRNA_synt_N, and to PF00750.10 tRNA-synt_1d. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.947 |
argS | guaB | Cla_1087 | Cla_1159 | arginyl-tRNA synthetase; Pfam matches to PF03485.7 Arg_tRNA_synt_N, and to PF00750.10 tRNA-synt_1d. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.406 |
argS | lysS | Cla_1087 | Cla_0488 | arginyl-tRNA synthetase; Pfam matches to PF03485.7 Arg_tRNA_synt_N, and to PF00750.10 tRNA-synt_1d. | lysyl-tRNA synthetase; Pfam matches to PF01336.16 tRNA_anti, and to PF00152.11 tRNA-synt_2; Belongs to the class-II aminoacyl-tRNA synthetase family. | 0.885 |
argS | pyrG | Cla_1087 | Cla_0012 | arginyl-tRNA synthetase; Pfam matches to PF03485.7 Arg_tRNA_synt_N, and to PF00750.10 tRNA-synt_1d. | CTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.853 |
argS | rpoB | Cla_1087 | Cla_0449 | arginyl-tRNA synthetase; Pfam matches to PF03485.7 Arg_tRNA_synt_N, and to PF00750.10 tRNA-synt_1d. | DNA-directed RNA polymerase, beta chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.887 |
argS | rpoC | Cla_1087 | Cla_0450 | arginyl-tRNA synthetase; Pfam matches to PF03485.7 Arg_tRNA_synt_N, and to PF00750.10 tRNA-synt_1d. | DNA-directed RNA polymerase, beta' chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.887 |
gmk | apt | Cla_1089 | Cla_0680 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.964 |
gmk | argS | Cla_1089 | Cla_1087 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | arginyl-tRNA synthetase; Pfam matches to PF03485.7 Arg_tRNA_synt_N, and to PF00750.10 tRNA-synt_1d. | 0.976 |
gmk | guaA | Cla_1089 | Cla_0501 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.970 |
gmk | guaB | Cla_1089 | Cla_1159 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.491 |
gmk | pyrG | Cla_1089 | Cla_0012 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | CTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.417 |