| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Cla_0537 | Cla_0538 | Cla_0537 | Cla_0538 | Conserved hypothetical integral membrane protein (DUF6 domain protein); Pfam match to PF00892.11 DUF6. | Purine/xanthine transport protein; Pfam match to PF00860.11 Xan_ur_permease. | 0.825 |
| Cla_0537 | kdsA | Cla_0537 | Cla_0539 | Conserved hypothetical integral membrane protein (DUF6 domain protein); Pfam match to PF00892.11 DUF6. | 3-deoxy-D-manno-2-octulosonate-8-phosphate synthase; Pfam match to PF00793.11 DAHP_synth_1; Belongs to the KdsA family. | 0.787 |
| Cla_0537 | nusB | Cla_0537 | Cla_0541 | Conserved hypothetical integral membrane protein (DUF6 domain protein); Pfam match to PF00892.11 DUF6. | Transcription antitermination factor NusB; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. | 0.770 |
| Cla_0537 | pyrF | Cla_0537 | Cla_0542 | Conserved hypothetical integral membrane protein (DUF6 domain protein); Pfam match to PF00892.11 DUF6. | Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. | 0.767 |
| Cla_0537 | ribH | Cla_0537 | Cla_0540 | Conserved hypothetical integral membrane protein (DUF6 domain protein); Pfam match to PF00892.11 DUF6. | Riboflavin synthase, beta subunit; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. | 0.767 |
| Cla_0538 | Cla_0537 | Cla_0538 | Cla_0537 | Purine/xanthine transport protein; Pfam match to PF00860.11 Xan_ur_permease. | Conserved hypothetical integral membrane protein (DUF6 domain protein); Pfam match to PF00892.11 DUF6. | 0.825 |
| Cla_0538 | carB | Cla_0538 | Cla_1395 | Purine/xanthine transport protein; Pfam match to PF00860.11 Xan_ur_permease. | Carbamoylphosphate synthase, large subunit; Pfam matches to PF00289.13 CPSase_L_chain, and to PF02786.8 CPSase_L_D2; Belongs to the CarB family. | 0.871 |
| Cla_0538 | kdsA | Cla_0538 | Cla_0539 | Purine/xanthine transport protein; Pfam match to PF00860.11 Xan_ur_permease. | 3-deoxy-D-manno-2-octulosonate-8-phosphate synthase; Pfam match to PF00793.11 DAHP_synth_1; Belongs to the KdsA family. | 0.787 |
| Cla_0538 | nusB | Cla_0538 | Cla_0541 | Purine/xanthine transport protein; Pfam match to PF00860.11 Xan_ur_permease. | Transcription antitermination factor NusB; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. | 0.767 |
| Cla_0538 | pyrB | Cla_0538 | Cla_1053 | Purine/xanthine transport protein; Pfam match to PF00860.11 Xan_ur_permease. | Aspartate carbamoyltransferase; Pfam matches to PF02729.12 OTCace_N, and to PF00185.15 OTCace; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.896 |
| Cla_0538 | pyrC2 | Cla_0538 | Cla_1205 | Purine/xanthine transport protein; Pfam match to PF00860.11 Xan_ur_permease. | Dihydroorotase; Pfam match to PF01979.11 Amidohydro_1. | 0.749 |
| Cla_0538 | pyrD | Cla_0538 | Cla_0628 | Purine/xanthine transport protein; Pfam match to PF00860.11 Xan_ur_permease. | Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. | 0.771 |
| Cla_0538 | pyrE | Cla_0538 | Cla_1509 | Purine/xanthine transport protein; Pfam match to PF00860.11 Xan_ur_permease. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.868 |
| Cla_0538 | pyrF | Cla_0538 | Cla_0542 | Purine/xanthine transport protein; Pfam match to PF00860.11 Xan_ur_permease. | Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. | 0.969 |
| Cla_0538 | ribH | Cla_0538 | Cla_0540 | Purine/xanthine transport protein; Pfam match to PF00860.11 Xan_ur_permease. | Riboflavin synthase, beta subunit; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. | 0.767 |
| carB | Cla_0538 | Cla_1395 | Cla_0538 | Carbamoylphosphate synthase, large subunit; Pfam matches to PF00289.13 CPSase_L_chain, and to PF02786.8 CPSase_L_D2; Belongs to the CarB family. | Purine/xanthine transport protein; Pfam match to PF00860.11 Xan_ur_permease. | 0.871 |
| carB | pyrB | Cla_1395 | Cla_1053 | Carbamoylphosphate synthase, large subunit; Pfam matches to PF00289.13 CPSase_L_chain, and to PF02786.8 CPSase_L_D2; Belongs to the CarB family. | Aspartate carbamoyltransferase; Pfam matches to PF02729.12 OTCace_N, and to PF00185.15 OTCace; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.999 |
| carB | pyrC2 | Cla_1395 | Cla_1205 | Carbamoylphosphate synthase, large subunit; Pfam matches to PF00289.13 CPSase_L_chain, and to PF02786.8 CPSase_L_D2; Belongs to the CarB family. | Dihydroorotase; Pfam match to PF01979.11 Amidohydro_1. | 0.935 |
| carB | pyrD | Cla_1395 | Cla_0628 | Carbamoylphosphate synthase, large subunit; Pfam matches to PF00289.13 CPSase_L_chain, and to PF02786.8 CPSase_L_D2; Belongs to the CarB family. | Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. | 0.943 |
| carB | pyrE | Cla_1395 | Cla_1509 | Carbamoylphosphate synthase, large subunit; Pfam matches to PF00289.13 CPSase_L_chain, and to PF02786.8 CPSase_L_D2; Belongs to the CarB family. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.919 |