Cla_0546 protein (Campylobacter lari) - STRING interaction network

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Score

Cla_0546

DnaJ-like protein; Pfam match to PF00226.22 DnaJ. (256 aa)

Predicted Functional Partners:

trmE

0.902

dnaK

0.894

por

0.840

Cla_0551

0.839

purH

0.833

grpE

0.832

purL

0.826

oxaA

0.820

htpG

0.819

rnpA

0.812

Your Current Organism:

Campylobacter lari

NCBI taxonomy Id: 306263
Other names: C. lari RM2100, Campylobacter lari RM2100, Campylobacter lari str. RM2100, Campylobacter lari strain RM2100

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Cla_0546	Cla_0551	Cla_0546	Cla_0551	DnaJ-like protein; Pfam match to PF00226.22 DnaJ.	Conserved hypothetical protein (DUF37 domain protein); Could be involved in insertion of integral membrane proteins into the membrane; Belongs to the UPF0161 family.	0.839
Cla_0546	dnaK	Cla_0546	Cla_0935	DnaJ-like protein; Pfam match to PF00226.22 DnaJ.	Chaperone and heat shock protein 70; Acts as a chaperone; Belongs to the heat shock protein 70 family.	0.894
Cla_0546	grpE	Cla_0546	Cla_0936	DnaJ-like protein; Pfam match to PF00226.22 DnaJ.	Co-chaperone protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of AT [...]	0.832
Cla_0546	htpG	Cla_0546	Cla_0703	DnaJ-like protein; Pfam match to PF00226.22 DnaJ.	Heat shock protein HtpG, chaperone Hsp90; Molecular chaperone. Has ATPase activity.	0.819
Cla_0546	oxaA	Cla_0546	Cla_0550	DnaJ-like protein; Pfam match to PF00226.22 DnaJ.	60 kDa inner-membrane protein; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.	0.820
Cla_0546	por	Cla_0546	Cla_0388	DnaJ-like protein; Pfam match to PF00226.22 DnaJ.	Pyruvate ferredoxin/flavodoxin oxidoreductase; Pfam matches to PF01855.10 POR_N, and to PF01558.9 POR.	0.840
Cla_0546	purH	Cla_0546	Cla_0545	DnaJ-like protein; Pfam match to PF00226.22 DnaJ.	Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Pfam matches to PF02142.13 MGS, and to PF01808.9 AICARFT_IMPCHas.	0.833
Cla_0546	purL	Cla_0546	Cla_0547	DnaJ-like protein; Pfam match to PF00226.22 DnaJ.	Phosphoribosylformylglycinamidine synthase, PurL subunit; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought [...]	0.826
Cla_0546	rnpA	Cla_0546	Cla_0552	DnaJ-like protein; Pfam match to PF00226.22 DnaJ.	Ribonuclease P protein component; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.	0.812
Cla_0546	trmE	Cla_0546	Cla_0548	DnaJ-like protein; Pfam match to PF00226.22 DnaJ.	tRNA modification GTPase, TrmE; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.	0.902
Cla_0551	Cla_0546	Cla_0551	Cla_0546	Conserved hypothetical protein (DUF37 domain protein); Could be involved in insertion of integral membrane proteins into the membrane; Belongs to the UPF0161 family.	DnaJ-like protein; Pfam match to PF00226.22 DnaJ.	0.839
Cla_0551	oxaA	Cla_0551	Cla_0550	Conserved hypothetical protein (DUF37 domain protein); Could be involved in insertion of integral membrane proteins into the membrane; Belongs to the UPF0161 family.	60 kDa inner-membrane protein; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.	0.967
Cla_0551	purH	Cla_0551	Cla_0545	Conserved hypothetical protein (DUF37 domain protein); Could be involved in insertion of integral membrane proteins into the membrane; Belongs to the UPF0161 family.	Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Pfam matches to PF02142.13 MGS, and to PF01808.9 AICARFT_IMPCHas.	0.812
Cla_0551	purL	Cla_0551	Cla_0547	Conserved hypothetical protein (DUF37 domain protein); Could be involved in insertion of integral membrane proteins into the membrane; Belongs to the UPF0161 family.	Phosphoribosylformylglycinamidine synthase, PurL subunit; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought [...]	0.812
Cla_0551	rnpA	Cla_0551	Cla_0552	Conserved hypothetical protein (DUF37 domain protein); Could be involved in insertion of integral membrane proteins into the membrane; Belongs to the UPF0161 family.	Ribonuclease P protein component; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.	0.982
Cla_0551	trmE	Cla_0551	Cla_0548	Conserved hypothetical protein (DUF37 domain protein); Could be involved in insertion of integral membrane proteins into the membrane; Belongs to the UPF0161 family.	tRNA modification GTPase, TrmE; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.	0.843
dnaK	Cla_0546	Cla_0935	Cla_0546	Chaperone and heat shock protein 70; Acts as a chaperone; Belongs to the heat shock protein 70 family.	DnaJ-like protein; Pfam match to PF00226.22 DnaJ.	0.894
dnaK	grpE	Cla_0935	Cla_0936	Chaperone and heat shock protein 70; Acts as a chaperone; Belongs to the heat shock protein 70 family.	Co-chaperone protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of AT [...]	0.999
dnaK	htpG	Cla_0935	Cla_0703	Chaperone and heat shock protein 70; Acts as a chaperone; Belongs to the heat shock protein 70 family.	Heat shock protein HtpG, chaperone Hsp90; Molecular chaperone. Has ATPase activity.	0.997
dnaK	por	Cla_0935	Cla_0388	Chaperone and heat shock protein 70; Acts as a chaperone; Belongs to the heat shock protein 70 family.	Pyruvate ferredoxin/flavodoxin oxidoreductase; Pfam matches to PF01855.10 POR_N, and to PF01558.9 POR.	0.591