| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ccoI | lon | Cla_0472 | Cla_0961 | Heavy metal translocating P-type ATPase; Pfam matches to PF00122.11 E1-E2_ATPase, and to PF00702.17 Hydrolase. | DNA-binding, ATP-dependent protease La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. | 0.811 |
| ccoI | pyrH | Cla_0472 | Cla_0615 | Heavy metal translocating P-type ATPase; Pfam matches to PF00122.11 E1-E2_ATPase, and to PF00702.17 Hydrolase. | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. | 0.810 |
| frr | ndk | Cla_1508 | Cla_1334 | Ribosome releasing factor; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.805 |
| frr | pyrH | Cla_1508 | Cla_0615 | Ribosome releasing factor; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family. | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. | 0.930 |
| frr | rplA | Cla_1508 | Cla_0446 | Ribosome releasing factor; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family. | 50S ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. | 0.978 |
| frr | rpsB | Cla_1508 | Cla_1094 | Ribosome releasing factor; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family. | Pfam match to PF00318.11 Ribosomal_S2; Belongs to the universal ribosomal protein uS2 family. | 0.990 |
| frr | tsf | Cla_1508 | Cla_1093 | Ribosome releasing factor; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family. | Translation elongation factor EF-Ts; Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Belongs to the EF-Ts family. | 0.947 |
| lon | ccoI | Cla_0961 | Cla_0472 | DNA-binding, ATP-dependent protease La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. | Heavy metal translocating P-type ATPase; Pfam matches to PF00122.11 E1-E2_ATPase, and to PF00702.17 Hydrolase. | 0.811 |
| lon | pyrH | Cla_0961 | Cla_0615 | DNA-binding, ATP-dependent protease La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. | 0.818 |
| ndk | frr | Cla_1334 | Cla_1508 | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | Ribosome releasing factor; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family. | 0.805 |
| ndk | pyrH | Cla_1334 | Cla_0615 | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. | 0.927 |
| ndk | rplA | Cla_1334 | Cla_0446 | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 50S ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. | 0.622 |
| ndk | rpsB | Cla_1334 | Cla_1094 | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | Pfam match to PF00318.11 Ribosomal_S2; Belongs to the universal ribosomal protein uS2 family. | 0.994 |
| ndk | spoT | Cla_1334 | Cla_0617 | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3' pyrophosphohydrolase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | 0.916 |
| ndk | tsf | Cla_1334 | Cla_1093 | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | Translation elongation factor EF-Ts; Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Belongs to the EF-Ts family. | 0.586 |
| pyrF | pyrH | Cla_0542 | Cla_0615 | Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. | 0.934 |
| pyrF | surE | Cla_0542 | Cla_1381 | Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. | Stationary-phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.915 |
| pyrH | ccoI | Cla_0615 | Cla_0472 | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. | Heavy metal translocating P-type ATPase; Pfam matches to PF00122.11 E1-E2_ATPase, and to PF00702.17 Hydrolase. | 0.810 |
| pyrH | frr | Cla_0615 | Cla_1508 | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. | Ribosome releasing factor; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family. | 0.930 |
| pyrH | lon | Cla_0615 | Cla_0961 | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. | DNA-binding, ATP-dependent protease La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. | 0.818 |
STRING v12.5 is now available!
