Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
cbpACo-chaperone-curved DNA binding protein A; Pfam matches to PF00226.22 DnaJ, and to PF01556.9 DnaJ_C. (288 aa)    
Predicted Functional Partners:
dnaK
Chaperone and heat shock protein 70; Acts as a chaperone; Belongs to the heat shock protein 70 family.
 0.993
hspR
Transcriptional regulator, MerR family; Pfam match to PF00376.14 MerR.
  
 
 0.963
grpE
Co-chaperone protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of AT [...]
 
 
 0.962
kefB
Sodium/hydrogen exchanger family protein; Pfam matches to PF00999.12 Na_H_Exchanger, and to PF02254.9 TrkA_N; Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family.
 
 
 
 0.872
groEL
60 kD chaperonin (cpn60); Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.
 
 0.870
hrcA
Heat-inducible transcription repressor.
  
  
 0.856
htpG
Heat shock protein HtpG, chaperone Hsp90; Molecular chaperone. Has ATPase activity.
   
 0.847
por
Pyruvate ferredoxin/flavodoxin oxidoreductase; Pfam matches to PF01855.10 POR_N, and to PF01558.9 POR.
   
 0.840
Cla_0772
Conserved hypothetical protein.
       0.770
Cla_0773
Conserved hypothetical protein (DUF2018 domain protein); Pfam match to PF09442.1 DUF2018.
       0.770
Your Current Organism:
Campylobacter lari
NCBI taxonomy Id: 306263
Other names: C. lari RM2100, Campylobacter lari RM2100, Campylobacter lari str. RM2100, Campylobacter lari strain RM2100
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