Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
macBABC transporter, ATP-binding protein; Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP- binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides. (643 aa)    
Predicted Functional Partners:
macA
AcrA/AcrE family efflux protein; Pfam match to PF00529.11 HlyD; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
 
 
 0.999
cmeA
RND efflux system, membrane fusion protein CmeA; Pfam match to PF00529.11 HlyD; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
 
 
 0.988
Cla_0917
Outer membrane efflux protein; Pfam match to PF02321.9 OEP.
 
 
 0.978
cmeE
Membrane fusion component of efflux system; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
  
 
 0.950
Cla_0842
Conserved hypothetical protein.
  
  
 0.931
Cla_0543
Conserved hypothetical META domain lipoprotein; Pfam match to PF03724.7 META.
    
   0.857
Cla_1166
ABC transporter, permease protein; Pfam match to PF02687.12 FtsX.
 
 
 0.845
cmeC
RND efflux system, outer membrane lipoprotein CmeC; Pfam matches to PF02321.9 OEP, and to PF02321.9 OEP.
 
 
 0.838
Cla_1167
ABC transporter, permease protein; Pfam match to PF02687.12 FtsX.
 
 
 0.836
rpoB
DNA-directed RNA polymerase, beta chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
     
 0.821
Your Current Organism:
Campylobacter lari
NCBI taxonomy Id: 306263
Other names: C. lari RM2100, Campylobacter lari RM2100, Campylobacter lari str. RM2100, Campylobacter lari strain RM2100
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