STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (340 aa)    
Predicted Functional Partners:
ilvH
Acetolactate synthase III, valine-sensitive, small subunit; Pfam match to PF01842.16 ACT.
 
 
 0.996
ilvB
Acetolactate synthase III, valine-sensitive, large subunit; Pfam matches to PF02776.9 TPP_enzyme_N, and to PF00205.13 TPP_enzyme_M.
 
 
 0.995
ilvD
Dihydroxyacid dehydratase; Pfam match to PF00920.12 ILVD_EDD; Belongs to the IlvD/Edd family.
 
 
 0.995
Cla_0944
NOL1/NOP2/sun family protein; Pfam match to PF01189.8 Nol1_Nop2_Fmu; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
       0.804
Cla_0945
Conserved hypothetical protein (UPF0081 domain protein); Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA; Belongs to the YqgF nuclease family.
       0.804
dprA
DNA processing protein A; Pfam match to PF02481.6 SMF.
       0.804
Cla_0947
Conserved hypothetical protein, polysaccharide deacetylase domain protein; Pfam match to PF04748.4 Polysacc_deac_2.
       0.804
thrC
Threonine synthase; Pfam match to PF00291.16 PALP.
  
  
 0.719
ilvA
Threonine dehydratase; Pfam match to PF00291.16 PALP.
  
  
 0.709
thrB
Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily.
  
  
 0.660
Your Current Organism:
Campylobacter lari
NCBI taxonomy Id: 306263
Other names: C. lari RM2100, Campylobacter lari RM2100, Campylobacter lari str. RM2100, Campylobacter lari strain RM2100
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.