Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene co-occurrence
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[Homology]
Score
hemDUroporphyrinogen III cosynthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (212 aa)    
Predicted Functional Partners:
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
  
 0.989
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
  
 
 0.926
thiE
Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
       0.825
thiM
Hydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family.
       0.825
thiD
Phosphomethylpyrimidine kinase; Pfam match to PF08543.3 Phos_pyr_kin.
       0.825
hemB
Delta-aminolevulinic acid dehydratase; Pfam match to PF00490.12 ALAD; Belongs to the ALAD family.
  
 
 0.812
ccsBA
Cytochrome c biogenesis protein, CcmF/CycK/CcsA family; Pfam match to PF01578.11 Cytochrom_C_asm.
 
    0.805
Cla_0809
Cytochrome c biogenesis protein; Pfam match to PF01578.11 Cytochrom_C_asm.
 
    0.800
Cla_1363
Conserved hypothetical integral membrane protein; Pfam match to PF03739.5 YjgP_YjgQ.
  
     0.749
atpF
ATP synthase F0 sector, B' subunit; Pfam match to PF00430.9 ATP-synt_B; Belongs to the ATPase B chain family.
  
     0.745
Your Current Organism:
Campylobacter lari
NCBI taxonomy Id: 306263
Other names: C. lari RM2100, Campylobacter lari RM2100, Campylobacter lari str. RM2100, Campylobacter lari strain RM2100
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