STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Coexpression
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[Homology]
Score
thiHThiamine biosynthesis ThiGH complex, ThiH subunit; Pfam matches to PF04055.12 Radical_SAM, and to PF06968.4 BATS. (377 aa)    
Predicted Functional Partners:
thiG
Thiamine biosynthesis ThiGH complex, ThiG subunit; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
 
 0.999
Cla_1146
Thiamine-phosphate pyrophosphorylase/regulatory protein TenI, putative; Pfam match to PF02581.8 TMP-TENI.
 
  
 0.973
thiS
Thiamine biosynthesis protein ThiS; Pfam match to PF02597.11 ThiS.
 
    0.964
thiF
ThiS adenylation protein ThiF; Pfam match to PF00899.12 ThiF.
 
    0.917
thiC
Thiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
  
  
 0.890
thiE
Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
  
  
 0.853
lctP
L-lactate permease; Transports L-lactate across the membrane. Can also transport D-lactate and glycolate; Belongs to the lactate permease family.
      
 0.777
cysE
Serine O-acetyltransferase.
      
 0.774
thiD
Phosphomethylpyrimidine kinase; Pfam match to PF08543.3 Phos_pyr_kin.
  
 
 0.745
Cla_0572
Metallophosphoesterase; Pfam match to PF00149.19 Metallophos.
      
 0.730
Your Current Organism:
Campylobacter lari
NCBI taxonomy Id: 306263
Other names: C. lari RM2100, Campylobacter lari RM2100, Campylobacter lari str. RM2100, Campylobacter lari strain RM2100
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.