| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Cla_0502 | Cla_1262 | Cla_0502 | Cla_1262 | Ribosomal RNA adenine dimethylase; Pfam match to PF08242.3 Methyltransf_12. | Phosphatidylserine decarboxylase related protein. | 0.914 |
| Cla_0502 | psd | Cla_0502 | Cla_0573 | Ribosomal RNA adenine dimethylase; Pfam match to PF08242.3 Methyltransf_12. | Phosphatidylserine decarboxylase; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). | 0.927 |
| Cla_0502 | pssA | Cla_0502 | Cla_1263 | Ribosomal RNA adenine dimethylase; Pfam match to PF08242.3 Methyltransf_12. | CDP-diacylglycerol--serine O-phosphatidyltransferase; Pfam match to PF01066.12 CDP-OH_P_transf; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.888 |
| Cla_1262 | Cla_0502 | Cla_1262 | Cla_0502 | Phosphatidylserine decarboxylase related protein. | Ribosomal RNA adenine dimethylase; Pfam match to PF08242.3 Methyltransf_12. | 0.914 |
| Cla_1262 | pgsA | Cla_1262 | Cla_0624 | Phosphatidylserine decarboxylase related protein. | CDP-1,2-diacyl-sn-glycero-3-phosphate phosphatidyltransferase; Pfam match to PF01066.12 CDP-OH_P_transf; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.512 |
| Cla_1262 | psd | Cla_1262 | Cla_0573 | Phosphatidylserine decarboxylase related protein. | Phosphatidylserine decarboxylase; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). | 0.900 |
| Cla_1262 | pssA | Cla_1262 | Cla_1263 | Phosphatidylserine decarboxylase related protein. | CDP-diacylglycerol--serine O-phosphatidyltransferase; Pfam match to PF01066.12 CDP-OH_P_transf; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.986 |
| cdsA | pgsA | Cla_1536 | Cla_0624 | Phosphatidate cytidylyltransferase; Pfam match to PF01148.11 CTP_transf_1. | CDP-1,2-diacyl-sn-glycero-3-phosphate phosphatidyltransferase; Pfam match to PF01066.12 CDP-OH_P_transf; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.936 |
| cdsA | pssA | Cla_1536 | Cla_1263 | Phosphatidate cytidylyltransferase; Pfam match to PF01148.11 CTP_transf_1. | CDP-diacylglycerol--serine O-phosphatidyltransferase; Pfam match to PF01066.12 CDP-OH_P_transf; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.923 |
| glyA | ilvA | Cla_0489 | Cla_0965 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Threonine dehydratase; Pfam match to PF00291.16 PALP. | 0.934 |
| glyA | pssA | Cla_0489 | Cla_1263 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | CDP-diacylglycerol--serine O-phosphatidyltransferase; Pfam match to PF01066.12 CDP-OH_P_transf; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.900 |
| glyA | sdaA | Cla_0489 | Cla_0085 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | L-serine dehydratase; Pfam matches to PF03315.6 SDH_beta, and to PF03313.6 SDH_alpha; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.957 |
| glyA | serB | Cla_0489 | Cla_1367 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 3-phosphoserine phosphatase; Pfam match to PF00702.17 Hydrolase. | 0.930 |
| glyA | trpB | Cla_0489 | Cla_1345 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.919 |
| ilvA | glyA | Cla_0965 | Cla_0489 | Threonine dehydratase; Pfam match to PF00291.16 PALP. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.934 |
| ilvA | pssA | Cla_0965 | Cla_1263 | Threonine dehydratase; Pfam match to PF00291.16 PALP. | CDP-diacylglycerol--serine O-phosphatidyltransferase; Pfam match to PF01066.12 CDP-OH_P_transf; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.900 |
| ilvA | sdaA | Cla_0965 | Cla_0085 | Threonine dehydratase; Pfam match to PF00291.16 PALP. | L-serine dehydratase; Pfam matches to PF03315.6 SDH_beta, and to PF03313.6 SDH_alpha; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.924 |
| ilvA | serB | Cla_0965 | Cla_1367 | Threonine dehydratase; Pfam match to PF00291.16 PALP. | 3-phosphoserine phosphatase; Pfam match to PF00702.17 Hydrolase. | 0.908 |
| ilvA | trpB | Cla_0965 | Cla_1345 | Threonine dehydratase; Pfam match to PF00291.16 PALP. | Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.927 |
| pgsA | Cla_1262 | Cla_0624 | Cla_1262 | CDP-1,2-diacyl-sn-glycero-3-phosphate phosphatidyltransferase; Pfam match to PF01066.12 CDP-OH_P_transf; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | Phosphatidylserine decarboxylase related protein. | 0.512 |