| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Cla_0457 | cstA | Cla_0457 | Cla_1348 | Sodium/proline symporter; Catalyzes the sodium-dependent uptake of extracellular L- proline; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. | Carbon starvation protein A; Pfam match to PF02554.5 CstA. | 0.593 |
| Cla_0457 | putA | Cla_0457 | Cla_0363 | Sodium/proline symporter; Catalyzes the sodium-dependent uptake of extracellular L- proline; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. | Proline dehydrogenase/delta-1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; Belongs to the aldehyde dehydrogenase family. In the N-terminal section; belongs to the proline dehydrogenase family. | 0.955 |
| Cla_1349 | cstA | Cla_1349 | Cla_1348 | Conserved hypothetical protein (DUF466 domain protein); Pfam match to PF04328.4 DUF466. | Carbon starvation protein A; Pfam match to PF02554.5 CstA. | 0.951 |
| Cla_1349 | uvrA | Cla_1349 | Cla_1347 | Conserved hypothetical protein (DUF466 domain protein); Pfam match to PF04328.4 DUF466. | Excinuclease ABC, subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. | 0.488 |
| cstA | Cla_0457 | Cla_1348 | Cla_0457 | Carbon starvation protein A; Pfam match to PF02554.5 CstA. | Sodium/proline symporter; Catalyzes the sodium-dependent uptake of extracellular L- proline; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. | 0.593 |
| cstA | Cla_1349 | Cla_1348 | Cla_1349 | Carbon starvation protein A; Pfam match to PF02554.5 CstA. | Conserved hypothetical protein (DUF466 domain protein); Pfam match to PF04328.4 DUF466. | 0.951 |
| cstA | glyA | Cla_1348 | Cla_0489 | Carbon starvation protein A; Pfam match to PF02554.5 CstA. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.596 |
| cstA | ispH | Cla_1348 | Cla_1191 | Carbon starvation protein A; Pfam match to PF02554.5 CstA. | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. | 0.839 |
| cstA | lpxA | Cla_1348 | Cla_1399 | Carbon starvation protein A; Pfam match to PF02554.5 CstA. | UDP-N-acetylglucosamine acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.476 |
| cstA | putA | Cla_1348 | Cla_0363 | Carbon starvation protein A; Pfam match to PF02554.5 CstA. | Proline dehydrogenase/delta-1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; Belongs to the aldehyde dehydrogenase family. In the N-terminal section; belongs to the proline dehydrogenase family. | 0.893 |
| cstA | putP | Cla_1348 | Cla_0364 | Carbon starvation protein A; Pfam match to PF02554.5 CstA. | Sodium/proline symporter; Catalyzes the sodium-dependent uptake of extracellular L- proline; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. | 0.643 |
| cstA | uvrA | Cla_1348 | Cla_1347 | Carbon starvation protein A; Pfam match to PF02554.5 CstA. | Excinuclease ABC, subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. | 0.488 |
| glyA | cstA | Cla_0489 | Cla_1348 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Carbon starvation protein A; Pfam match to PF02554.5 CstA. | 0.596 |
| glyA | lpxA | Cla_0489 | Cla_1399 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | UDP-N-acetylglucosamine acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.637 |
| ispH | cstA | Cla_1191 | Cla_1348 | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. | Carbon starvation protein A; Pfam match to PF02554.5 CstA. | 0.839 |
| lpxA | cstA | Cla_1399 | Cla_1348 | UDP-N-acetylglucosamine acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | Carbon starvation protein A; Pfam match to PF02554.5 CstA. | 0.476 |
| lpxA | glyA | Cla_1399 | Cla_0489 | UDP-N-acetylglucosamine acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.637 |
| putA | Cla_0457 | Cla_0363 | Cla_0457 | Proline dehydrogenase/delta-1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; Belongs to the aldehyde dehydrogenase family. In the N-terminal section; belongs to the proline dehydrogenase family. | Sodium/proline symporter; Catalyzes the sodium-dependent uptake of extracellular L- proline; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. | 0.955 |
| putA | cstA | Cla_0363 | Cla_1348 | Proline dehydrogenase/delta-1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; Belongs to the aldehyde dehydrogenase family. In the N-terminal section; belongs to the proline dehydrogenase family. | Carbon starvation protein A; Pfam match to PF02554.5 CstA. | 0.893 |
| putA | putP | Cla_0363 | Cla_0364 | Proline dehydrogenase/delta-1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; Belongs to the aldehyde dehydrogenase family. In the N-terminal section; belongs to the proline dehydrogenase family. | Sodium/proline symporter; Catalyzes the sodium-dependent uptake of extracellular L- proline; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. | 0.994 |