| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| cheA | hisC | Cla_1369 | Cla_1359 | Chemotaxis protein CheA; Pfam matches to PF01627.14 Hpt, and to PF02895.5 H-kinase_dim. | Histidinol-phosphate aminotransferase; Pfam match to PF00155.12 Aminotran_1_2; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.695 |
| cheA | serB | Cla_1369 | Cla_1367 | Chemotaxis protein CheA; Pfam matches to PF01627.14 Hpt, and to PF02895.5 H-kinase_dim. | 3-phosphoserine phosphatase; Pfam match to PF00702.17 Hydrolase. | 0.817 |
| cheA | serC | Cla_1369 | Cla_1350 | Chemotaxis protein CheA; Pfam matches to PF01627.14 Hpt, and to PF02895.5 H-kinase_dim. | Phosphohydroxythreonine transaminase/phosphoserine transaminase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. | 0.452 |
| cysE | glyA | Cla_0747 | Cla_0489 | Serine O-acetyltransferase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.845 |
| cysE | ilvA | Cla_0747 | Cla_0965 | Serine O-acetyltransferase. | Threonine dehydratase; Pfam match to PF00291.16 PALP. | 0.804 |
| cysE | pssA | Cla_0747 | Cla_1263 | Serine O-acetyltransferase. | CDP-diacylglycerol--serine O-phosphatidyltransferase; Pfam match to PF01066.12 CDP-OH_P_transf; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.800 |
| cysE | sdaA | Cla_0747 | Cla_0085 | Serine O-acetyltransferase. | L-serine dehydratase; Pfam matches to PF03315.6 SDH_beta, and to PF03313.6 SDH_alpha; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.912 |
| cysE | serB | Cla_0747 | Cla_1367 | Serine O-acetyltransferase. | 3-phosphoserine phosphatase; Pfam match to PF00702.17 Hydrolase. | 0.851 |
| cysE | trpB | Cla_0747 | Cla_1345 | Serine O-acetyltransferase. | Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.804 |
| glyA | cysE | Cla_0489 | Cla_0747 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Serine O-acetyltransferase. | 0.845 |
| glyA | ilvA | Cla_0489 | Cla_0965 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Threonine dehydratase; Pfam match to PF00291.16 PALP. | 0.923 |
| glyA | pssA | Cla_0489 | Cla_1263 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | CDP-diacylglycerol--serine O-phosphatidyltransferase; Pfam match to PF01066.12 CDP-OH_P_transf; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.900 |
| glyA | sdaA | Cla_0489 | Cla_0085 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | L-serine dehydratase; Pfam matches to PF03315.6 SDH_beta, and to PF03313.6 SDH_alpha; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.963 |
| glyA | serB | Cla_0489 | Cla_1367 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 3-phosphoserine phosphatase; Pfam match to PF00702.17 Hydrolase. | 0.932 |
| glyA | serC | Cla_0489 | Cla_1350 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Phosphohydroxythreonine transaminase/phosphoserine transaminase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. | 0.618 |
| glyA | trpB | Cla_0489 | Cla_1345 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.923 |
| hisC | cheA | Cla_1359 | Cla_1369 | Histidinol-phosphate aminotransferase; Pfam match to PF00155.12 Aminotran_1_2; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | Chemotaxis protein CheA; Pfam matches to PF01627.14 Hpt, and to PF02895.5 H-kinase_dim. | 0.695 |
| hisC | hisIE | Cla_1359 | Cla_0104 | Histidinol-phosphate aminotransferase; Pfam match to PF00155.12 Aminotran_1_2; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | phosphoribosyl-AMP cyclohydrolase/ phosphoribosyl-ATP pyrophosphohydrolase; Pfam matches to PF01502.9 PRA-CH, and to PF01503.8 PRA-PH; In the N-terminal section; belongs to the PRA-CH family. | 0.999 |
| hisC | serB | Cla_1359 | Cla_1367 | Histidinol-phosphate aminotransferase; Pfam match to PF00155.12 Aminotran_1_2; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 3-phosphoserine phosphatase; Pfam match to PF00702.17 Hydrolase. | 0.857 |
| hisC | serC | Cla_1359 | Cla_1350 | Histidinol-phosphate aminotransferase; Pfam match to PF00155.12 Aminotran_1_2; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | Phosphohydroxythreonine transaminase/phosphoserine transaminase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. | 0.640 |