STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cmeARND efflux system, membrane fusion protein CmeA; Pfam match to PF00529.11 HlyD; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (365 aa)    
Predicted Functional Partners:
cmeB
RND efflux system, inner membrane transporter CmeB; Pfam match to PF00873.10 ACR_tran.
 0.999
cmeC
RND efflux system, outer membrane lipoprotein CmeC; Pfam matches to PF02321.9 OEP, and to PF02321.9 OEP.
 
 0.998
cmeF
Integral membrane component of efflux system; Pfam match to PF00873.10 ACR_tran; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
 
 0.996
macB
ABC transporter, ATP-binding protein; Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP- binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.
 
 
 0.988
cmeD
Outer membrane component of efflux system; Pfam matches to PF02321.9 OEP, and to PF02321.9 OEP.
  
 0.982
cmeE
Membrane fusion component of efflux system; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
  
  
 0.976
cmeR
Transcriptional regulator, TetR family; Pfam match to PF00440.14 TetR_N.
 
   
 0.900
Cla_0917
Outer membrane efflux protein; Pfam match to PF02321.9 OEP.
 
 
 0.822
gyrA
DNA gyrase, subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
   
  
 0.782
gltX1
glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
   
  
 0.779
Your Current Organism:
Campylobacter lari
NCBI taxonomy Id: 306263
Other names: C. lari RM2100, Campylobacter lari RM2100, Campylobacter lari str. RM2100, Campylobacter lari strain RM2100
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