GCA_000317205_02477 protein (Fischerella muscicola)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

GCA_000317205_02477

Unannotated protein. (169 aa)

Predicted Functional Partners:

GCA_000317205_04073

0.846

GCA_000317205_01815

0.843

GCA_000317205_00044

0.819

GCA_000317205_02023

0.812

GCA_000317205_03461

0.779

GCA_000317205_02059

0.777

GCA_000317205_02082

0.777

GCA_000317205_04008

0.777

GCA_000317205_00469

0.755

GCA_000317205_00705

0.755

Your Current Organism:

Fischerella muscicola

NCBI taxonomy Id: 306281
Other names: F. muscicola PCC 7414, Fischerella muscicola PCC 7414, Fischerella sp. (strain PCC 7414), Fischerella sp. PCC 7414

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structured XML interaction data, according to the 'PSI-MI' data standard

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... functional annotations:

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
GCA_000317205_00044	GCA_000317205_02059	Unannotated protein.	Unannotated protein.	0.757
GCA_000317205_00044	GCA_000317205_02082	Unannotated protein.	Unannotated protein.	0.757
GCA_000317205_00044	GCA_000317205_02477	Unannotated protein.	Unannotated protein.	0.819
GCA_000317205_00469	GCA_000317205_01815	Unannotated protein.	Unannotated protein.	0.860
GCA_000317205_00469	GCA_000317205_02477	Unannotated protein.	Unannotated protein.	0.755
GCA_000317205_00705	GCA_000317205_01815	Unannotated protein.	Unannotated protein.	0.847
GCA_000317205_00705	GCA_000317205_02477	Unannotated protein.	Unannotated protein.	0.755
GCA_000317205_01815	GCA_000317205_00469	Unannotated protein.	Unannotated protein.	0.860
GCA_000317205_01815	GCA_000317205_00705	Unannotated protein.	Unannotated protein.	0.847
GCA_000317205_01815	GCA_000317205_02023	Unannotated protein.	Unannotated protein.	0.896
GCA_000317205_01815	GCA_000317205_02082	Unannotated protein.	Unannotated protein.	0.440
GCA_000317205_01815	GCA_000317205_02477	Unannotated protein.	Unannotated protein.	0.843
GCA_000317205_02023	GCA_000317205_01815	Unannotated protein.	Unannotated protein.	0.896
GCA_000317205_02023	GCA_000317205_02059	Unannotated protein.	Unannotated protein.	0.846
GCA_000317205_02023	GCA_000317205_02477	Unannotated protein.	Unannotated protein.	0.812
GCA_000317205_02059	GCA_000317205_00044	Unannotated protein.	Unannotated protein.	0.757
GCA_000317205_02059	GCA_000317205_02023	Unannotated protein.	Unannotated protein.	0.846
GCA_000317205_02059	GCA_000317205_02082	Unannotated protein.	Unannotated protein.	0.877
GCA_000317205_02059	GCA_000317205_02477	Unannotated protein.	Unannotated protein.	0.777
GCA_000317205_02059	GCA_000317205_03461	Unannotated protein.	Unannotated protein.	0.962

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

29

average node degree:

5.27

avg. local clustering coefficient:

0.72

expected number of edges:

11

PPI enrichment p-value:

4.36e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000160

Phosphorelay signal transduction system

10 of 92

1.57

3.24

1.61e-12

GO:0018106

Peptidyl-histidine phosphorylation

4 of 42

1.52

1.35

0.00064

GO:0050794

Regulation of cellular process

11 of 447

0.93

1.09

1.20e-08

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000155

Phosphorelay sensor kinase activity

5 of 47

1.56

1.63

0.00011

GO:0003677

DNA binding

6 of 379

0.74

0.47

0.0197

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4765

Mixed, incl. LytTr DNA-binding domain, and Sensor histidine kinase NatK, C-terminal domain

7 of 14

2.24

5.02

1.43e-11

CL:4783

Histidine kinase, and Bacterial transcriptional activator domain

4 of 5

2.44

3.12

1.02e-06

CL:4767

LytTr DNA-binding domain, and Sensor histidine kinase NatK, C-terminal domain

2 of 6

2.06

0.81

0.0302

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map02020

Two-component system

11 of 307

1.09

1.52

1.38e-10

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0597

Phosphoprotein

6 of 53

1.59

2.23

9.45e-07

KW-0805

Transcription regulation

6 of 176

1.07

0.97

0.00042

KW-0418

Kinase

4 of 106

1.11

0.75

0.0094

KW-0238

DNA-binding

5 of 274

0.8

0.48

0.0265

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001789

Signal transduction response regulator, receiver domain

6 of 43

1.68

2.29

2.07e-06

IPR011006

CheY-like superfamily

6 of 46

1.65

2.24

2.07e-06

IPR046947

Transcriptional regulatory protein LytR-like

3 of 5

2.32

1.76

0.00047

IPR007492

LytTR DNA-binding domain

3 of 5

2.32

1.76

0.00047

IPR005467

Histidine kinase domain

4 of 35

1.6

1.37

0.00084

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00448

cheY-homologous receiver domain

6 of 43

1.68

2.59

1.64e-07

SM00850

LytTr DNA-binding domain

3 of 5

2.32

2.22

5.60e-05

SM01043

Bacterial transcriptional activator domain

2 of 2

2.54

1.57

0.0013

SM00387

Histidine kinase-like ATPases

4 of 43

1.51

1.47

0.00024

SM00388

His Kinase A (phosphoacceptor) domain

3 of 31

1.52

1.17

0.0023

(more ...)

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