node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SFP08169.1 | gyrB | SAMN05421839_10560 | SAMN05421839_12736 | 5'-3' exonuclease. | DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.620 |
SFP08169.1 | metG | SAMN05421839_10560 | SAMN05421839_14518 | 5'-3' exonuclease. | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | 0.654 |
SFP08169.1 | parC | SAMN05421839_10560 | SAMN05421839_10933 | 5'-3' exonuclease. | Topoisomerase-4 subunit A; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 2 subfamily. | 0.549 |
SFP08169.1 | parE | SAMN05421839_10560 | SAMN05421839_10934 | 5'-3' exonuclease. | Topoisomerase-4 subunit B; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 2 subfamily. | 0.620 |
SFP08169.1 | secD | SAMN05421839_10560 | SAMN05421839_101107 | 5'-3' exonuclease. | SecD/SecF fusion protein; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA; Belongs to the SecD/SecF family. SecD subfamily. | 0.553 |
SFP40238.1 | nusA | SAMN05421839_11825 | SAMN05421839_10284 | 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase /chorismate mutase. | N utilization substance protein A; Participates in both transcription termination and antitermination. | 0.536 |
SFP40238.1 | parC | SAMN05421839_11825 | SAMN05421839_10933 | 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase /chorismate mutase. | Topoisomerase-4 subunit A; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 2 subfamily. | 0.642 |
SFP46614.1 | SFP75918.1 | SAMN05421839_12232 | SAMN05421839_1561 | Signal peptidase I; Belongs to the peptidase S26 family. | Signal peptidase I; Belongs to the peptidase S26 family. | 0.810 |
SFP46614.1 | nusA | SAMN05421839_12232 | SAMN05421839_10284 | Signal peptidase I; Belongs to the peptidase S26 family. | N utilization substance protein A; Participates in both transcription termination and antitermination. | 0.537 |
SFP46614.1 | parC | SAMN05421839_12232 | SAMN05421839_10933 | Signal peptidase I; Belongs to the peptidase S26 family. | Topoisomerase-4 subunit A; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 2 subfamily. | 0.576 |
SFP46614.1 | secD | SAMN05421839_12232 | SAMN05421839_101107 | Signal peptidase I; Belongs to the peptidase S26 family. | SecD/SecF fusion protein; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA; Belongs to the SecD/SecF family. SecD subfamily. | 0.579 |
SFP75918.1 | SFP46614.1 | SAMN05421839_1561 | SAMN05421839_12232 | Signal peptidase I; Belongs to the peptidase S26 family. | Signal peptidase I; Belongs to the peptidase S26 family. | 0.810 |
SFP75918.1 | nusA | SAMN05421839_1561 | SAMN05421839_10284 | Signal peptidase I; Belongs to the peptidase S26 family. | N utilization substance protein A; Participates in both transcription termination and antitermination. | 0.537 |
SFP75918.1 | parC | SAMN05421839_1561 | SAMN05421839_10933 | Signal peptidase I; Belongs to the peptidase S26 family. | Topoisomerase-4 subunit A; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 2 subfamily. | 0.576 |
SFP75918.1 | secD | SAMN05421839_1561 | SAMN05421839_101107 | Signal peptidase I; Belongs to the peptidase S26 family. | SecD/SecF fusion protein; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA; Belongs to the SecD/SecF family. SecD subfamily. | 0.579 |
fliE | parC | SAMN05421839_102126 | SAMN05421839_10933 | Flagellar hook-basal body complex protein FliE. | Topoisomerase-4 subunit A; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 2 subfamily. | 0.571 |
gyrB | SFP08169.1 | SAMN05421839_12736 | SAMN05421839_10560 | DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 5'-3' exonuclease. | 0.620 |
gyrB | metG | SAMN05421839_12736 | SAMN05421839_14518 | DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | 0.518 |
gyrB | parC | SAMN05421839_12736 | SAMN05421839_10933 | DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | Topoisomerase-4 subunit A; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 2 subfamily. | 0.995 |
gyrB | secD | SAMN05421839_12736 | SAMN05421839_101107 | DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | SecD/SecF fusion protein; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA; Belongs to the SecD/SecF family. SecD subfamily. | 0.495 |