node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SFS85382.1 | SFS95706.1 | SAMN05421668_11335 | SAMN05421668_12119 | ATP-dependent Clp protease ATP-binding subunit ClpE; Belongs to the ClpA/ClpB family. | Plasmid segregation protein ParM. | 0.941 |
SFS85382.1 | dnaJ | SAMN05421668_11335 | SAMN05421668_102111 | ATP-dependent Clp protease ATP-binding subunit ClpE; Belongs to the ClpA/ClpB family. | Molecular chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...] | 0.882 |
SFS85382.1 | dnaK | SAMN05421668_11335 | SAMN05421668_102110 | ATP-dependent Clp protease ATP-binding subunit ClpE; Belongs to the ClpA/ClpB family. | Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.943 |
SFS85382.1 | groL | SAMN05421668_11335 | SAMN05421668_11843 | ATP-dependent Clp protease ATP-binding subunit ClpE; Belongs to the ClpA/ClpB family. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.652 |
SFS85382.1 | groS | SAMN05421668_11335 | SAMN05421668_11844 | ATP-dependent Clp protease ATP-binding subunit ClpE; Belongs to the ClpA/ClpB family. | Chaperonin GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.713 |
SFS85382.1 | grpE | SAMN05421668_11335 | SAMN05421668_102109 | ATP-dependent Clp protease ATP-binding subunit ClpE; Belongs to the ClpA/ClpB family. | Molecular chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP [...] | 0.801 |
SFS85382.1 | hrcA | SAMN05421668_11335 | SAMN05421668_102108 | ATP-dependent Clp protease ATP-binding subunit ClpE; Belongs to the ClpA/ClpB family. | Heat-inducible transcriptional repressor; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.583 |
SFS85382.1 | hslU | SAMN05421668_11335 | SAMN05421668_10478 | ATP-dependent Clp protease ATP-binding subunit ClpE; Belongs to the ClpA/ClpB family. | ATP-dependent HslUV protease ATP-binding subunit HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. | 0.581 |
SFS85382.1 | hslV | SAMN05421668_11335 | SAMN05421668_10477 | ATP-dependent Clp protease ATP-binding subunit ClpE; Belongs to the ClpA/ClpB family. | ATP-dependent HslUV protease, peptidase subunit HslV; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. | 0.464 |
SFS85382.1 | htpG | SAMN05421668_11335 | SAMN05421668_11213 | ATP-dependent Clp protease ATP-binding subunit ClpE; Belongs to the ClpA/ClpB family. | Molecular chaperone HtpG; Molecular chaperone. Has ATPase activity. | 0.748 |
SFS95706.1 | SFS85382.1 | SAMN05421668_12119 | SAMN05421668_11335 | Plasmid segregation protein ParM. | ATP-dependent Clp protease ATP-binding subunit ClpE; Belongs to the ClpA/ClpB family. | 0.941 |
SFS95706.1 | dnaJ | SAMN05421668_12119 | SAMN05421668_102111 | Plasmid segregation protein ParM. | Molecular chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...] | 0.990 |
SFS95706.1 | groL | SAMN05421668_12119 | SAMN05421668_11843 | Plasmid segregation protein ParM. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.935 |
SFS95706.1 | groS | SAMN05421668_12119 | SAMN05421668_11844 | Plasmid segregation protein ParM. | Chaperonin GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.838 |
SFS95706.1 | grpE | SAMN05421668_12119 | SAMN05421668_102109 | Plasmid segregation protein ParM. | Molecular chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP [...] | 0.981 |
SFS95706.1 | hrcA | SAMN05421668_12119 | SAMN05421668_102108 | Plasmid segregation protein ParM. | Heat-inducible transcriptional repressor; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.782 |
SFS95706.1 | hslU | SAMN05421668_12119 | SAMN05421668_10478 | Plasmid segregation protein ParM. | ATP-dependent HslUV protease ATP-binding subunit HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. | 0.577 |
SFS95706.1 | hslV | SAMN05421668_12119 | SAMN05421668_10477 | Plasmid segregation protein ParM. | ATP-dependent HslUV protease, peptidase subunit HslV; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. | 0.526 |
SFS95706.1 | htpG | SAMN05421668_12119 | SAMN05421668_11213 | Plasmid segregation protein ParM. | Molecular chaperone HtpG; Molecular chaperone. Has ATPase activity. | 0.988 |
dnaJ | SFS85382.1 | SAMN05421668_102111 | SAMN05421668_11335 | Molecular chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...] | ATP-dependent Clp protease ATP-binding subunit ClpE; Belongs to the ClpA/ClpB family. | 0.882 |