node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CHGG_00616 | CHGG_01028 | Q2HGN8 | Q2HFH6 | Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. | ERCC4 domain-containing protein. | 0.898 |
CHGG_00616 | CHGG_03342 | Q2HGN8 | Q2H8W2 | Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. | Uncharacterized protein. | 0.865 |
CHGG_00616 | CHGG_05793 | Q2HGN8 | Q2H6C2 | Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | 0.993 |
CHGG_00616 | CHGG_06264 | Q2HGN8 | Q2H501 | Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. | Uncharacterized protein; Belongs to the PI3/PI4-kinase family. | 0.980 |
CHGG_00616 | CHGG_09021 | Q2HGN8 | Q2GSN3 | Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. | Uncharacterized protein. | 0.497 |
CHGG_00616 | CHGG_09109 | Q2HGN8 | Q2GSE5 | Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. | Polyubiquitin. | 0.585 |
CHGG_00616 | CHGG_09124 | Q2HGN8 | Q2GSD0 | Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. | Uncharacterized protein. | 0.831 |
CHGG_00616 | CHGG_09685 | Q2HGN8 | Q2GQR9 | Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. | RMI1_N domain-containing protein. | 0.955 |
CHGG_00616 | MPH1 | Q2HGN8 | Q2HG76 | Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. | ATP-dependent DNA helicase MPH1; ATP-dependent DNA helicase involved in DNA damage repair by homologous recombination and in genome maintenance. Capable of unwinding D-loops. Plays a role in limiting crossover recombinants during mitotic DNA double-strand break (DSB) repair. Component of a FANCM-MHF complex which promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork. Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily. | 0.958 |
CHGG_01028 | CHGG_00616 | Q2HFH6 | Q2HGN8 | ERCC4 domain-containing protein. | Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. | 0.898 |
CHGG_01028 | CHGG_02830 | Q2HFH6 | Q2HAC4 | ERCC4 domain-containing protein. | MPN domain-containing protein. | 0.809 |
CHGG_01028 | CHGG_03342 | Q2HFH6 | Q2H8W2 | ERCC4 domain-containing protein. | Uncharacterized protein. | 0.865 |
CHGG_01028 | CHGG_05793 | Q2HFH6 | Q2H6C2 | ERCC4 domain-containing protein. | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | 0.926 |
CHGG_01028 | CHGG_06264 | Q2HFH6 | Q2H501 | ERCC4 domain-containing protein. | Uncharacterized protein; Belongs to the PI3/PI4-kinase family. | 0.820 |
CHGG_01028 | CHGG_09021 | Q2HFH6 | Q2GSN3 | ERCC4 domain-containing protein. | Uncharacterized protein. | 0.849 |
CHGG_01028 | CHGG_09109 | Q2HFH6 | Q2GSE5 | ERCC4 domain-containing protein. | Polyubiquitin. | 0.469 |
CHGG_01028 | CHGG_09124 | Q2HFH6 | Q2GSD0 | ERCC4 domain-containing protein. | Uncharacterized protein. | 0.978 |
CHGG_01028 | CHGG_09685 | Q2HFH6 | Q2GQR9 | ERCC4 domain-containing protein. | RMI1_N domain-containing protein. | 0.947 |
CHGG_01028 | MPH1 | Q2HFH6 | Q2HG76 | ERCC4 domain-containing protein. | ATP-dependent DNA helicase MPH1; ATP-dependent DNA helicase involved in DNA damage repair by homologous recombination and in genome maintenance. Capable of unwinding D-loops. Plays a role in limiting crossover recombinants during mitotic DNA double-strand break (DSB) repair. Component of a FANCM-MHF complex which promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork. Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily. | 0.910 |
CHGG_02830 | CHGG_01028 | Q2HAC4 | Q2HFH6 | MPN domain-containing protein. | ERCC4 domain-containing protein. | 0.809 |