STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
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[Homology]
Score
MSH3DNA mismatch repair protein MSH3; Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. MSH3 provides substrate- binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch bindi [...] (1156 aa)    
Predicted Functional Partners:
CHGG_09614
DNA mismatch repair protein msh-2; Component of the post-replicative DNA mismatch repair system (MMR).
  
0.999
CHGG_09761
DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).
  
 
0.992
CHGG_00977
DNA_MISMATCH_REPAIR_2 domain-containing protein.
  
0.969
CHGG_05318
PX domain-containing protein.
    
   0.949
CHGG_09798
Zn(2)-C6 fungal-type domain-containing protein.
    
 0.942
CHGG_02733
DNA_mis_repair domain-containing protein.
 
 0.895
CHGG_04646
Uncharacterized protein.
 
 0.875
CHGG_04545
Uncharacterized protein.
 
 0.872
CHGG_10508
MutL_C domain-containing protein.
  
 0.829
CHGG_04645
DNA_mis_repair domain-containing protein.
  
 0.819
Your Current Organism:
Chaetomium globosum
NCBI taxonomy Id: 306901
Other names: C. globosum CBS 148.51, Chaetomium globosum CBS 148.51
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