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The next version of STRING is ready for use in your analyses: updated networks across STRING newly available directed regulatory networks a new typed view showing functional, physical, and regulatory edges in one network new clustering options and cluster-based layouts … and much more!
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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
git2G protein-coupled receptor kinase interacting ArfGAP 2a. (728 aa)    
Predicted Functional Partners:
LOC112138373
Rho guanine nucleotide exchange factor (GEF) 7b.
    
 0.903
arhgef6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6.
    
 0.903
arhgef7
Rho guanine nucleotide exchange factor (GEF) 7a.
    
 0.903
LOC112150209
Leupaxin.
    
 0.872
LOC112148168
Uncharacterized protein.
    
 0.872
TGFB1I1
Transforming growth factor beta-1-induced transcript 1 protein; Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways.
    
 0.872
ENSOMEP00000022558
Paxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family.
    
 0.872
PAK3
Non-specific serine/threonine protein kinase.
    
 0.757
pak1
Non-specific serine/threonine protein kinase.
    
 0.757
CDC42
Cell division cycle 42.
    
 0.745
Your Current Organism:
Oryzias melastigma
NCBI taxonomy Id: 30732
Other names: Aplocheilus melastigmus, Indian medaka, Java medaka, O. melastigma, marine medaka
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