STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LOC112155766NEDD8 ubiquitin like modifier. (80 aa)    
Predicted Functional Partners:
mysm1
Myb-like, SWIRM and MPN domains 1.
   
 0.995
ENSOMEP00000036131
UBX domain protein 7.
    
 0.994
rbx1
Ring-box 1, E3 ubiquitin protein ligase.
   
 0.988
ENSOMEP00000006412
SUMO peptidase family member, NEDD8 specific.
    
 0.982
cops5
COP9 signalosome subunit 5.
   
 0.982
cul1
Cullin 1b; Belongs to the cullin family.
    
 0.982
COPS6
COP9 signalosome subunit 6.
   
 0.981
nae1
NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.
   
 0.981
cul2
Cullin 2; Belongs to the cullin family.
    
 0.979
gps1
G protein pathway suppressor 1.
    
 0.972
Your Current Organism:
Oryzias melastigma
NCBI taxonomy Id: 30732
Other names: Aplocheilus melastigmus, Indian medaka, Java medaka, O. melastigma, marine medaka
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