node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FEN1 | Rsub_01530 | A0A2V0PG22 | A0A2V0NN90 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | P-loop containing nucleoside triphosphate hydrolase. | 0.892 |
FEN1 | Rsub_02451 | A0A2V0PG22 | A0A2V0NZV2 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | DNA polymerase. | 0.861 |
FEN1 | Rsub_03364 | A0A2V0PG22 | A0A2V0NRH6 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | DNA replication ATP-dependent helicase nuclease. | 0.839 |
FEN1 | Rsub_04260 | A0A2V0PG22 | A0A2V0P113 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | DNA primase large subunit-like. | 0.818 |
FEN1 | Rsub_05269 | A0A2V0PG22 | A0A2V0P4S0 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Exonuclease. | 0.792 |
FEN1 | Rsub_06007 | A0A2V0PG22 | A0A2V0P861 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Double-strand break repair protein. | 0.958 |
FEN1 | Rsub_06407 | A0A2V0PG22 | A0A2V0P1C3 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Replication A 70 kDa DNA-binding subunit A. | 0.661 |
FEN1 | Rsub_06865 | A0A2V0PG22 | A0A2V0P1W6 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Replication protein A subunit; Component of the replication protein A complex (RPA) required for DNA recombination, repair and replication. The activity of RPA is mediated by single-stranded DNA binding and protein interactions. Probably involved in repair of double-strand DNA breaks (DSBs) induced by genotoxic stresses. | 0.661 |
FEN1 | Rsub_12921 | A0A2V0PG22 | A0A2V0PKL9 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | WD_REPEATS_REGION domain-containing protein. | 0.640 |
Rsub_00612 | Rsub_01530 | A0A2V0NQS1 | A0A2V0NN90 | Flap endonuclease GEN-like protein. | P-loop containing nucleoside triphosphate hydrolase. | 0.892 |
Rsub_00612 | Rsub_02451 | A0A2V0NQS1 | A0A2V0NZV2 | Flap endonuclease GEN-like protein. | DNA polymerase. | 0.861 |
Rsub_00612 | Rsub_03364 | A0A2V0NQS1 | A0A2V0NRH6 | Flap endonuclease GEN-like protein. | DNA replication ATP-dependent helicase nuclease. | 0.839 |
Rsub_00612 | Rsub_04260 | A0A2V0NQS1 | A0A2V0P113 | Flap endonuclease GEN-like protein. | DNA primase large subunit-like. | 0.818 |
Rsub_00612 | Rsub_05269 | A0A2V0NQS1 | A0A2V0P4S0 | Flap endonuclease GEN-like protein. | Exonuclease. | 0.792 |
Rsub_00612 | Rsub_06007 | A0A2V0NQS1 | A0A2V0P861 | Flap endonuclease GEN-like protein. | Double-strand break repair protein. | 0.958 |
Rsub_00612 | Rsub_06407 | A0A2V0NQS1 | A0A2V0P1C3 | Flap endonuclease GEN-like protein. | Replication A 70 kDa DNA-binding subunit A. | 0.661 |
Rsub_00612 | Rsub_06865 | A0A2V0NQS1 | A0A2V0P1W6 | Flap endonuclease GEN-like protein. | Replication protein A subunit; Component of the replication protein A complex (RPA) required for DNA recombination, repair and replication. The activity of RPA is mediated by single-stranded DNA binding and protein interactions. Probably involved in repair of double-strand DNA breaks (DSBs) induced by genotoxic stresses. | 0.661 |
Rsub_00612 | Rsub_12921 | A0A2V0NQS1 | A0A2V0PKL9 | Flap endonuclease GEN-like protein. | WD_REPEATS_REGION domain-containing protein. | 0.640 |
Rsub_01530 | FEN1 | A0A2V0NN90 | A0A2V0PG22 | P-loop containing nucleoside triphosphate hydrolase. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.892 |
Rsub_01530 | Rsub_00612 | A0A2V0NN90 | A0A2V0NQS1 | P-loop containing nucleoside triphosphate hydrolase. | Flap endonuclease GEN-like protein. | 0.892 |