STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SIR92352.1Hydroxymethylbilane synthase. (374 aa)    
Predicted Functional Partners:
SIR92375.1
uroporphyrinogen-III synthase.
 
 0.999
SIR92363.1
uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family.
 
 0.998
SIR91192.1
Porphobilinogen synthase; Belongs to the ALAD family.
 
 0.998
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
 0.986
hemA
glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
  
 0.977
hemL
Glutamate-1-semialdehyde 2,1-aminomutase.
 
  
 0.930
SIR97619.1
Chlorite dismutase.
 
   
 0.878
SIR67559.1
Precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase.
 
 
 0.845
SIR74384.1
Precorrin-2/cobalt-factor-2 C20-methyltransferase.
 
  
 0.760
hemH
Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family.
 
  
 0.722
Your Current Organism:
Natronorubrum thiooxidans
NCBI taxonomy Id: 308853
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