sgaT protein (Coprothermobacter proteolyticus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

sgaT

PTS ascorbate transporter subunit IIC; Derived by automated computational analysis using gene prediction method: Protein Homology. (451 aa)

Predicted Functional Partners:

sgaB2

0.995

sgaB1

0.983

ptsN

0.981

ACI18185.1

0.913

hpr

0.906

ACI16999.1

0.506

ACI17573.2

0.506

ACI16823.1

0.506

ACI17646.1

0.483

Your Current Organism:

Coprothermobacter proteolyticus

NCBI taxonomy Id: 309798
Other names: C. proteolyticus DSM 5265, Coprothermobacter proteolyticus DSM 5265

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACI16823.1	ACI16999.1	COPRO5265_0850	COPRO5265_0848	Dihydrolipoyllysine succinyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Acetoin:2,6-dichlorophenolindophenol oxidoreductase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.948
ACI16823.1	ACI17573.2	COPRO5265_0850	COPRO5265_0849	Dihydrolipoyllysine succinyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.968
ACI16823.1	ACI17646.1	COPRO5265_0850	COPRO5265_0218	Dihydrolipoyllysine succinyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	FruA; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.443
ACI16823.1	sgaB2	COPRO5265_0850	COPRO5265_0846	Dihydrolipoyllysine succinyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	PTS ascorbate transporter subunit IIB; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.497
ACI16823.1	sgaT	COPRO5265_0850	COPRO5265_0847	Dihydrolipoyllysine succinyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	PTS ascorbate transporter subunit IIC; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.506
ACI16999.1	ACI16823.1	COPRO5265_0848	COPRO5265_0850	Acetoin:2,6-dichlorophenolindophenol oxidoreductase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology.	Dihydrolipoyllysine succinyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.948
ACI16999.1	ACI17573.2	COPRO5265_0848	COPRO5265_0849	Acetoin:2,6-dichlorophenolindophenol oxidoreductase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology.	Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
ACI16999.1	sgaB2	COPRO5265_0848	COPRO5265_0846	Acetoin:2,6-dichlorophenolindophenol oxidoreductase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology.	PTS ascorbate transporter subunit IIB; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.497
ACI16999.1	sgaT	COPRO5265_0848	COPRO5265_0847	Acetoin:2,6-dichlorophenolindophenol oxidoreductase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology.	PTS ascorbate transporter subunit IIC; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.506
ACI17573.2	ACI16823.1	COPRO5265_0849	COPRO5265_0850	Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Dihydrolipoyllysine succinyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.968
ACI17573.2	ACI16999.1	COPRO5265_0849	COPRO5265_0848	Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Acetoin:2,6-dichlorophenolindophenol oxidoreductase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
ACI17573.2	sgaB2	COPRO5265_0849	COPRO5265_0846	Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	PTS ascorbate transporter subunit IIB; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.497
ACI17573.2	sgaT	COPRO5265_0849	COPRO5265_0847	Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	PTS ascorbate transporter subunit IIC; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.506
ACI17646.1	ACI16823.1	COPRO5265_0218	COPRO5265_0850	FruA; Derived by automated computational analysis using gene prediction method: Protein Homology.	Dihydrolipoyllysine succinyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.443
ACI17646.1	ACI18185.1	COPRO5265_0218	COPRO5265_0028	FruA; Derived by automated computational analysis using gene prediction method: Protein Homology.	PTS ascorbate transporter subunit IIC; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.483
ACI17646.1	hpr	COPRO5265_0218	COPRO5265_1343	FruA; Derived by automated computational analysis using gene prediction method: Protein Homology.	PTS sugar transporter subunit IIA; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.992
ACI17646.1	ptsN	COPRO5265_0218	COPRO5265_0027	FruA; Derived by automated computational analysis using gene prediction method: Protein Homology.	PTS maltose transporter subunit IIBC; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.739
ACI17646.1	sgaB1	COPRO5265_0218	COPRO5265_0029	FruA; Derived by automated computational analysis using gene prediction method: Protein Homology.	PTS sugar transporter subunit IIBC; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.455
ACI17646.1	sgaB2	COPRO5265_0218	COPRO5265_0846	FruA; Derived by automated computational analysis using gene prediction method: Protein Homology.	PTS ascorbate transporter subunit IIB; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.455
ACI17646.1	sgaT	COPRO5265_0218	COPRO5265_0847	FruA; Derived by automated computational analysis using gene prediction method: Protein Homology.	PTS ascorbate transporter subunit IIC; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.483

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

48

average node degree:

8.73

avg. local clustering coefficient:

0.933

expected number of edges:

11

PPI enrichment p-value:

1.11e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008299

Isoprenoid biosynthetic process

9 of 27

2.8

9.97

2.02e-20

GO:0016126

Sterol biosynthetic process

7 of 37

2.55

6.68

3.71e-14

GO:0046165

Alcohol biosynthetic process

8 of 87

2.24

6.02

3.00e-14

GO:1901617

Organic hydroxy compound biosynthetic process

9 of 132

2.11

5.91

3.32e-15

GO:0006695

Cholesterol biosynthetic process

6 of 27

2.62

5.84

3.98e-12

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004659

Prenyltransferase activity

4 of 15

2.7

3.57

2.14e-07

GO:0016765

Transferase activity, transferring alkyl or aryl (other than methyl) groups

5 of 49

2.29

3.46

1.16e-07

GO:0004337

Geranyltranstransferase activity

2 of 3

3.1

1.53

0.0017

GO:0004161

Dimethylallyltranstransferase activity

2 of 3

3.1

1.53

0.0017

GO:0016709

Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

2 of 23

2.22

0.8

0.0333

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:1904423

Dehydrodolichyl diphosphate synthase complex

2 of 2

3.28

1.51

0.0019

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:5410

Isoprenoid biosynthetic process

8 of 15

3.0

9.98

1.04e-19

CL:5304

Steroid biosynthetic process, and Prenyltransferase activity

11 of 78

2.43

9.91

2.05e-23

CL:5413

Terpenoid backbone biosynthesis

7 of 8

3.22

9.37

4.27e-18

CL:5316

Steroid biosynthesis, and 3-beta hydroxysteroid dehydrogenase/isomerase family

3 of 21

2.43

2.07

0.00013

CL:5319

Steroid biosynthesis

2 of 8

2.68

1.32

0.0040

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

hcq00900

Terpenoid backbone biosynthesis

7 of 19

2.84

8.3

1.05e-16

hcq00100

Steroid biosynthesis

3 of 23

2.39

2.52

1.56e-05

hcq01100

Metabolic pathways

9 of 1363

1.1

1.38

9.08e-08

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-191273

Cholesterol biosynthesis

8 of 31

2.69

8.39

1.89e-17

MAP-8957322

Metabolism of steroids

8 of 165

1.96

4.58

2.55e-12

MAP-446199

Synthesis of Dolichyl-phosphate

3 of 6

2.98

2.97

3.80e-06

MAP-556833

Metabolism of lipids

8 of 948

1.2

1.48

1.53e-06

MAP-446219

Synthesis of substrates in N-glycan biosythesis

3 of 86

1.82

1.23

0.0034

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:1904423

Dehydrodolichyl diphosphate synthase complex

2 of 5

2.88

1.16

0.0080

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0756

Sterol biosynthesis

2 of 4

2.98

1.61

0.0012

KW-0752

Steroid biosynthesis

2 of 4

2.98

1.61

0.0012

KW-0808

Transferase

5 of 961

0.99

0.73

0.0051

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01255

Putative undecaprenyl diphosphate synthase

2 of 2

3.28

1.37

0.0034

PF00348

Polyprenyl synthetase

2 of 4

2.98

1.31

0.0043

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036424

Decaprenyl diphosphate synthase-like superfamily

2 of 2

3.28

1.1

0.0106

IPR033749

Polyprenyl synthetase, conserved site

2 of 3

3.1

1.1

0.0106

IPR000092

Polyprenyl synthetase

2 of 4

2.98

1.09

0.0106

IPR008949

Isoprenoid synthase domain superfamily

2 of 6

2.8

1.06

0.0123

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (24%) [HD]

Permalink

Network

Neighborhood

Experiments

Fusion

Databases

Cooccurrence

Textmining

Coexpression

© STRING Consortium 2024

Credits

Access

Info

About