ACI18820.1 protein (Dictyoglomus thermophilum)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

ACI18820.1

Zmpste24; Identified by match to protein family HMM PF01435. (412 aa)

Predicted Functional Partners:

nadE-2

0.787

ACI19144.1

0.632

ftsH

0.609

glnA_2

0.540

grpE

0.423

dnaJ

0.410

Your Current Organism:

Dictyoglomus thermophilum

NCBI taxonomy Id: 309799
Other names: D. thermophilum H-6-12, Dictyoglomus thermophilum H-6-12

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACI18820.1	ACI19144.1	DICTH_1908	DICTH_1910	Zmpste24; Identified by match to protein family HMM PF01435.	Transketolase, putative; Identified by match to protein family HMM PF00456; match to protein family HMM PF02779; match to protein family HMM PF02780.	0.632
ACI18820.1	dnaJ	DICTH_1908	DICTH_1724	Zmpste24; Identified by match to protein family HMM PF01435.	Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]	0.410
ACI18820.1	ftsH	DICTH_1908	DICTH_0713	Zmpste24; Identified by match to protein family HMM PF01435.	Cell division protein FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family.	0.609
ACI18820.1	glnA_2	DICTH_1908	DICTH_1907	Zmpste24; Identified by match to protein family HMM PF01435.	Glutamine synthetase, type I; Identified by match to protein family HMM PF00120; match to protein family HMM PF03951; match to protein family HMM TIGR00653; Belongs to the glutamine synthetase family.	0.540
ACI18820.1	grpE	DICTH_1908	DICTH_1721	Zmpste24; Identified by match to protein family HMM PF01435.	Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...]	0.423
ACI18820.1	nadE-2	DICTH_1908	DICTH_1909	Zmpste24; Identified by match to protein family HMM PF01435.	NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.	0.787
ACI19144.1	ACI18820.1	DICTH_1910	DICTH_1908	Transketolase, putative; Identified by match to protein family HMM PF00456; match to protein family HMM PF02779; match to protein family HMM PF02780.	Zmpste24; Identified by match to protein family HMM PF01435.	0.632
ACI19144.1	glnA_2	DICTH_1910	DICTH_1907	Transketolase, putative; Identified by match to protein family HMM PF00456; match to protein family HMM PF02779; match to protein family HMM PF02780.	Glutamine synthetase, type I; Identified by match to protein family HMM PF00120; match to protein family HMM PF03951; match to protein family HMM TIGR00653; Belongs to the glutamine synthetase family.	0.505
ACI19144.1	nadE-2	DICTH_1910	DICTH_1909	Transketolase, putative; Identified by match to protein family HMM PF00456; match to protein family HMM PF02779; match to protein family HMM PF02780.	NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.	0.791
dnaJ	ACI18820.1	DICTH_1724	DICTH_1908	Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]	Zmpste24; Identified by match to protein family HMM PF01435.	0.410
dnaJ	ftsH	DICTH_1724	DICTH_0713	Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]	Cell division protein FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family.	0.617
dnaJ	grpE	DICTH_1724	DICTH_1721	Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]	Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...]	0.999
ftsH	ACI18820.1	DICTH_0713	DICTH_1908	Cell division protein FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family.	Zmpste24; Identified by match to protein family HMM PF01435.	0.609
ftsH	dnaJ	DICTH_0713	DICTH_1724	Cell division protein FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family.	Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]	0.617
ftsH	grpE	DICTH_0713	DICTH_1721	Cell division protein FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family.	Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...]	0.445
glnA_2	ACI18820.1	DICTH_1907	DICTH_1908	Glutamine synthetase, type I; Identified by match to protein family HMM PF00120; match to protein family HMM PF03951; match to protein family HMM TIGR00653; Belongs to the glutamine synthetase family.	Zmpste24; Identified by match to protein family HMM PF01435.	0.540
glnA_2	ACI19144.1	DICTH_1907	DICTH_1910	Glutamine synthetase, type I; Identified by match to protein family HMM PF00120; match to protein family HMM PF03951; match to protein family HMM TIGR00653; Belongs to the glutamine synthetase family.	Transketolase, putative; Identified by match to protein family HMM PF00456; match to protein family HMM PF02779; match to protein family HMM PF02780.	0.505
glnA_2	nadE-2	DICTH_1907	DICTH_1909	Glutamine synthetase, type I; Identified by match to protein family HMM PF00120; match to protein family HMM PF03951; match to protein family HMM TIGR00653; Belongs to the glutamine synthetase family.	NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.	0.737
grpE	ACI18820.1	DICTH_1721	DICTH_1908	Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...]	Zmpste24; Identified by match to protein family HMM PF01435.	0.423
grpE	dnaJ	DICTH_1721	DICTH_1724	Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...]	Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]	0.999